Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice.

التفاصيل البيبلوغرافية
العنوان:	Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice.
المؤلفون:	Bart Lammers, Ying Zhao, Amanda C Foks, Reeni B Hildebrand, Johan Kuiper, Theo J C Van Berkel, Miranda Van Eck
المصدر:	PLoS ONE, Vol 7, Iss 10, p e48080 (2012)
بيانات النشر:	Public Library of Science (PLoS), 2012.
سنة النشر:	2012
المجموعة:	LCC:Medicine LCC:Science
مصطلحات موضوعية:	Medicine, Science
الوصف:	ATP-binding cassette transporter A1 (ABCA1) is an important mediator of macrophage cholesterol efflux. It mediates the efflux of cellular cholesterol to lipid-poor apolipoprotein A-I. LDL receptor (LDLr) knockout (KO) mice deficient for leukocyte ABCA1 (ABCA1 KO→LDLr KO) show increased atherosclerosis and splenic lipid accumulation despite largely attenuated serum cholesterol levels. In the present study, we aimed to explore the importance of the spleen for the atheroprotective effects of leukocyte ABCA1.LDLr KO mice were transplanted with bone marrow from ABCA1 KO mice or wild-type (WT) controls. After 8 weeks recovery, mice were either splenectomized (SP-x) or underwent a sham operation, and were subsequently challenged with a Western-type diet (WTD).In agreement with previous studies, the atherosclerotic lesion area in ABCA1 KO→LDLr KO sham animals (655 ± 82 × 10(3) µm(2)) was 1.4-fold (p = 0.03) larger compared to sham WT→LDLr KO mice (459 ± 33 × 10(3) µm(2)) after 8 weeks WTD feeding, despite 1.7-fold (p
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	1932-6203
Relation:	http://europepmc.org/articles/PMC3485037?pdf=render; https://doaj.org/toc/1932-6203
DOI:	10.1371/journal.pone.0048080
URL الوصول:	https://doaj.org/article/bef2f50d46114fbb99d7838faa1cf370
رقم الانضمام:	edsdoj.bef2f50d46114fbb99d7838faa1cf370
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	19326203
DOI:	10.1371/journal.pone.0048080