Academic Journal
Effectiveness and Economic Evaluation of Polyene Phosphatidyl Choline in Patients With Liver Diseases Based on Real-World Research
| العنوان: | Effectiveness and Economic Evaluation of Polyene Phosphatidyl Choline in Patients With Liver Diseases Based on Real-World Research |
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| المؤلفون: | Jian-Gao Fan, Ying Li, Ze Yu, Xing-Xian Luo, Ping Zheng, Xin Hao, Ze-Yuan Wang, Fei Gao, Guo-Qing Zhang, Wan-Yu Feng |
| المصدر: | Frontiers in Pharmacology, Vol 13 (2022) |
| بيانات النشر: | Frontiers Media S.A., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | polyene phosphatidyl choline, liver protective drug, liver disease, real-world research, effectiveness, economic evaluation, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Aims: Liver disease has high prevalence, number, and disease burden in China, and polyene phosphatidyl choline (PPC) is a widely used liver protective drug. We aim to explore the effectiveness and economy of PPC in patients with liver diseases based on real-world research and compare with other hepatoprotective drugs.Methods: This is a “three-phase” study from three medical centers, including descriptive study of patients using PPC injection, self-control case study of patients using PPC injection, and specific-disease cohort study of patients using PPC injection or control drugs. The major measurements of liver function for effectiveness analysis were the alanine transaminase (ALT) level changes and recovery rate. The main statistical methods were Wilcoxon signed rank test, χ2 test, and Mann–Whitney U test. Propensity score matching was applied to reduce bias. Cost-effectiveness analysis, cost minimization analysis, and sensitivity analysis were used for economic evaluation.Results: PPC alone or in combination with glutathione and magnesium isoglycyrrhizinate shows less total hospitalization cost (p < 0.05) and smaller cost-effectiveness ratio and was effective in protecting liver function, especially in patients with liver transplantation or postoperation of nontumor liver disease (ALT decreased significantly after PPC treatment; p < 0.05). Glutathione and magnesium isoglycyrrhizinate combined with PPC could enhance the protective function of liver.Conclusion: PPC was an effective and economic liver protective drug in patients with specific liver diseases, and PPC could enhance the liver protective function of glutathione and magnesium isoglycyrrhizinate. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1663-9812 94048258 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fphar.2022.806787/full; https://doaj.org/toc/1663-9812 |
| DOI: | 10.3389/fphar.2022.806787 |
| URL الوصول: | https://doaj.org/article/bea1a763e94048258c703d1507889d1f |
| رقم الانضمام: | edsdoj.bea1a763e94048258c703d1507889d1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16639812 94048258 |
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| DOI: | 10.3389/fphar.2022.806787 |