التفاصيل البيبلوغرافية
| العنوان: |
BNT162b2 or CoronaVac as the Third Dose against Omicron: Neutralizing Antibody Responses among Transplant Recipients Who Had Received Two Doses of CoronaVac |
| المؤلفون: |
Çiğdem Erol, Zeynep Ece Kuloğlu, Bircan Kayaaslan, Gülen Esken, Adalet Altunsoy, Tayfun Barlas, Güle Çınar, İmran Hasanoğlu, Ebru Oruç, Said İncir, Alpay Azap, Gülten Korkmaz, Dilara Turan Gökçe, Onur Elvan Kırımker, Ezgi Coşkun Yenigün, Erkan Ölçücüoğlu, Ebru Ayvazoğlu Soy, Süleyman Çetinkünar, Özlem Kurt Azap, Füsun Can, Mehmet Haberal |
| المصدر: |
Viruses, Vol 15, Iss 7, p 1534 (2023) |
| بيانات النشر: |
MDPI AG, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
solid organ transplantation, hematopoietic stem cell transplantation, mRNA vaccine, inactivated vaccine, neutralizing antibody, Anti-Spike IgG, Microbiology, QR1-502 |
| الوصف: |
We evaluated neutralizing antibodies against the Omicron variant and Anti-Spike IgG response in solid organ (SOT) or hematopoietic stem cell (HSTC) recipients after a third dose of BNT162b2 (BNT) or CoronaVac (CV) following two doses of CV. In total, 95 participants underwent SOT (n = 62; 44 liver, 18 kidney) or HSCT (n = 27; 5 allogeneic, 22 autologous) were included from five centers in Turkey. The median time between third doses and serum sampling was 154 days (range between 15 to 381). The vaccine-induced antibody responses of both neutralizing antibodies and Anti-Spike IgGs were assessed by plaque neutralizing assay and immunoassay, respectively. Neutralizing antibody and Anti-Spike IgG levels were significantly higher in transplant patients receiving BNT compared to those receiving CV (Geometric mean (GMT):26.76 vs. 10.89; p = 0.03 and 2116 Au/mL vs. 172.1 Au/mL; p < 0.001). Solid organ transplantation recipients, particularly liver transplant recipients, showed lower antibody levels than HSCT recipients. Thus, among HSCT recipients, the GMT after BNT was 91.29 and it was 15.81 in the SOT group (p < 0.001). In SOT, antibody levels after BNT in kidney transplantation recipients were significantly higher than those in liver transplantation recipients (GMT: 48.32 vs. 11.72) (p < 0.001). Moreover, the neutralizing antibody levels after CV were very low (GMT: 10.81) in kidney transplantation recipients and below the detection limit ( |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/15/7/1534; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v15071534 |
| URL الوصول: |
https://doaj.org/article/be9ce951a83742f28394dac5a80914cd |
| رقم الانضمام: |
edsdoj.be9ce951a83742f28394dac5a80914cd |
| قاعدة البيانات: |
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