Academic Journal
Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells
| العنوان: | Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells |
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| المؤلفون: | Hirofumi Noguchi, Jesse Garcia Castillo, Kinichi Nakashima, Samuel J Pleasure |
| المصدر: | eLife, Vol 8 (2019) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | stem cell, dentate gyrus, sonic hedgehog, hippocampal development, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Adult hippocampal neurogenesis requires the quiescent neural stem cell (NSC) pool to persist lifelong. However, establishment and maintenance of quiescent NSC pools during development is not understood. Here, we show that Suppressor of Fused (Sufu) controls establishment of the quiescent NSC pool during mouse dentate gyrus (DG) development by regulating Sonic Hedgehog (Shh) signaling activity. Deletion of Sufu in NSCs early in DG development decreases Shh signaling activity leading to reduced proliferation of NSCs, resulting in a small quiescent NSC pool in adult mice. We found that putative adult NSCs proliferate and increase their numbers in the first postnatal week and subsequently enter a quiescent state towards the end of the first postnatal week. In the absence of Sufu, postnatal expansion of NSCs is compromised, and NSCs prematurely become quiescent. Thus, Sufu is required for Shh signaling activity ensuring expansion and proper transition of NSC pools to quiescent states during DG development. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/42918; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.42918 |
| URL الوصول: | https://doaj.org/article/bdf3dfc5a4e741fb9f61ba7e48df3729 |
| رقم الانضمام: | edsdoj.bdf3dfc5a4e741fb9f61ba7e48df3729 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.42918 |