التفاصيل البيبلوغرافية
| العنوان: |
Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval |
| المؤلفون: |
Sandra Gattas, Myra Sarai Larson, Lilit Mnatsakanyan, Indranil Sen-Gupta, Sumeet Vadera, A. Lee Swindlehurst, Paul E. Rapp, Jack J. Lin, Michael A. Yassa |
| المصدر: |
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023) |
| بيانات النشر: |
Nature Portfolio, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Abstract Episodic memory arises as a function of dynamic interactions between the hippocampus and the neocortex, yet the mechanisms have remained elusive. Here, using human intracranial recordings during a mnemonic discrimination task, we report that 4-5 Hz (theta) power is differentially recruited during discrimination vs. overgeneralization, and its phase supports hippocampal-neocortical when memories are being formed and correctly retrieved. Interactions were largely bidirectional, with small but significant net directional biases; a hippocampus-to-neocortex bias during acquisition of new information that was subsequently correctly discriminated, and a neocortex-to-hippocampus bias during accurate discrimination of new stimuli from similar previously learned stimuli. The 4-5 Hz rhythm may facilitate the initial stages of information acquisition by neocortex during learning and the recall of stored information from cortex during retrieval. Future work should further probe these dynamics across different types of tasks and stimuli and computational models may need to be expanded accordingly to accommodate these findings. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-023-44011-6 |
| URL الوصول: |
https://doaj.org/article/bd633e8337ea4e5bb0bbc238dab78f40 |
| رقم الانضمام: |
edsdoj.bd633e8337ea4e5bb0bbc238dab78f40 |
| قاعدة البيانات: |
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