التفاصيل البيبلوغرافية
| العنوان: |
Sexually dimorphic metabolism of branched-chain lipids in C57BL/6J mice |
| المؤلفون: |
Barbara P. Atshaves, H. Ross Payne, Avery L. McIntosh, Shane E. Tichy, David Russell, Ann B. Kier, Friedhelm Schroeder |
| المصدر: |
Journal of Lipid Research, Vol 45, Iss 5, Pp 812-830 (2004) |
| بيانات النشر: |
Elsevier, 2004. |
| سنة النشر: |
2004 |
| المجموعة: |
LCC:Biochemistry |
| مصطلحات موضوعية: |
sterol carrier protein-2, sterol carrier protein-x, liver fatty acid binding protein, peroxisome proliferator-activated receptor α, peroxisome, phytanic acid, Biochemistry, QD415-436 |
| الوصف: |
Despite the importance of branched chain lipid oxidation in detoxification, almost nothing is known regarding factors regulating peroxisomal uptake, targeting, and metabolism. One peroxisomal protein, sterol carrier protein-x (SCP-x), is thought to catalyze a key thiolytic step in branched chain lipid oxidation. When mice with substantially lower hepatic levels of SCP-x were tested for susceptibility to dietary stress with phytol (a phytanic acid precursor and peroxisome proliferator), livers of phytol-fed female but not male mice i) accumulated phytol metabolites (phytanic acid, pristanic acid, and Δ-2,3-pristanic acid); ii) exhibited decreased fat tissue mass and increased liver mass/body mass; iii) displayed signs of histopathological lesions in the liver; and iv) demonstrated significant alterations in hepatic lipid distributions. Moreover, both male and female mice exhibited phytol-induced peroxisomal proliferation, as demonstrated by liver morphology and upregulation of the peroxisomal protein catalase. In addition, levels of liver fatty acid binding protein, along with SCP-2 and SCP-x, increased, suggesting upregulation mediated by phytanic acid, a known ligand agonist of the peroxisomal proliferator-activated receptor α.In summary, the present work establishes a role for SCP-x in branched chain lipid catabolism and demonstrates a sexual dimorphic response to phytol, a precursor of phytanic acid, in lipid parameters and hepatotoxicity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0022-2275 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0022227520318216; https://doaj.org/toc/0022-2275 |
| DOI: |
10.1194/jlr.M300408-JLR200 |
| URL الوصول: |
https://doaj.org/article/bd3737ff3cd241f6a358352cdaa29e6b |
| رقم الانضمام: |
edsdoj.bd3737ff3cd241f6a358352cdaa29e6b |
| قاعدة البيانات: |
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