التفاصيل البيبلوغرافية
| العنوان: |
Research progress in Beclin-1 and P62 in osteoporosis |
| المؤلفون: |
Jin Wenjun, Zheng Lin, Luo Shanshan, Cheng Yuting, Gong Zipeng, Liao Jian |
| المصدر: |
Xin yixue, Vol 55, Iss 2, Pp 81-86 (2024) |
| بيانات النشر: |
Editorial Office of Journal of New Medicine, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
autophagy, osteoporosis, p62, beclin-1, targeted therapy, Medicine |
| الوصف: |
Osteoporosis （OP） is a bone disease characterized by systemic bone loss and destruction of bone microstructure. The fundamental cause is the imbalance between bone formation and bone resorption mediated by osteoblasts and osteoclasts，and bone resorption is greater than bone formation. Autophagy plays an important role in the occurrence and development of osteoporosis，and the change of autophagy level is a key factor affecting bone balance. Studies have confirmed that autophagy-related molecules of Beclin-1 and P62 directly regulate the formation of autophagosomes at different levels，thus affecting the occurrence and development of OP. In this article，the expression mechanism，functional characteristics and targeted therapy of Beclin-1 and P62 in OP were reviewed，aiming to provide a theoretical basis for the prevention，treatment and subsequent research of OP. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
Chinese |
| تدمد: |
0253-9802 |
| Relation: |
https://www.xinyixue.cn/fileup/0253-9802/PDF/1709536328508-1701812045.pdf; https://doaj.org/toc/0253-9802 |
| DOI: |
10.3969/j.issn.0253-9802.2024.02.001 |
| URL الوصول: |
https://doaj.org/article/bd24dd619da14063a4a0a995b323a333 |
| رقم الانضمام: |
edsdoj.bd24dd619da14063a4a0a995b323a333 |
| قاعدة البيانات: |
Directory of Open Access Journals |