Academic Journal
Prolidase activity in women with polycystic ovarian syndrome undergoing assisted conception
| العنوان: | Prolidase activity in women with polycystic ovarian syndrome undergoing assisted conception |
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| المؤلفون: | Kadriye Erdoğan, Emine Utlu Özen, İnci Kahyaoğlu, Salim Neselioglu, Özcan Erel, Serra Akar, Özhan Özdemir, Cihangir Mutlu Ercan, Yaprak Engin Üstün |
| المصدر: | Journal of Obstetrics and Gynaecology, Vol 44, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | Assisted conception, polycystic ovary syndrome, prolidase activity, Gynecology and obstetrics, RG1-991 |
| الوصف: | Background Prolidase is a manganese (Mn)-dependent cytosolic exopeptidase that degrades imidodipeptides with C-terminal proline or hydroxyproline. Prolidase recycling from imidodipeptides plays a critical role in collagen resynthesis and extracellular matrix (ECM) remodelling. Following an increase in gonadotropins, ovarian and follicular collagen undergo substantial degradation. Abnormal ovarian ECM composition is associated with polycystic ovary syndrome (PCOS). This study aimed to examine prolidase activity in the serum and follicular fluid (FF) of women undergoing in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) treatment, comparing those with PCOS to those with normal ovarian function.Methods This prospective study enrolled 50 participants, of whom 44 were included. PCOS diagnosis followed the Rotterdam consensus criteria, with 20 patients constituting the study group. The control group comprised 24 individuals with mild-to-moderate male infertility. Prolidase enzyme activity in serum and FF was measured using the Chinard reagent via spectrophotometric analysis and compared between the groups.Results Serum and FF prolidase levels were significantly lower in patients with PCOS (p 0.05). A negative correlation existed between serum prolidase levels and total antral follicle (AF) count (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 01443615 1364-6893 0144-3615 |
| Relation: | https://doaj.org/toc/0144-3615; https://doaj.org/toc/1364-6893 |
| DOI: | 10.1080/01443615.2024.2346228 |
| URL الوصول: | https://doaj.org/article/bd00b7c323464e6f9dbaa984e62ae8fa |
| رقم الانضمام: | edsdoj.bd00b7c323464e6f9dbaa984e62ae8fa |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 01443615 13646893 |
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| DOI: | 10.1080/01443615.2024.2346228 |