Academic Journal
Longitudinal study of CSF biomarkers in patients with Alzheimer's disease.
| العنوان: | Longitudinal study of CSF biomarkers in patients with Alzheimer's disease. |
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| المؤلفون: | Peder Buchhave, Kaj Blennow, Henrik Zetterberg, Erik Stomrud, Elisabet Londos, Niels Andreasen, Lennart Minthon, Oskar Hansson |
| المصدر: | PLoS ONE, Vol 4, Iss 7, p e6294 (2009) |
| بيانات النشر: | Public Library of Science (PLoS), 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | BACKGROUND: The CSF biomarkers tau and Abeta42 can identify patients with AD, even during the preclinical stages. However, previous studies on longitudinal changes of tau and Abeta42 in individual patients with AD and elderly controls report somewhat inconsistent results. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the levels of tau and Abeta42 at baseline and after 1 year in 100 patients with AD. In a second cohort of 45 AD patients we measured the CSF biomarkers at baseline and after 2 years. Moreover, in 34 healthy elderly controls the CSF biomarkers were followed for 4 years. The baseline levels of tau were increased with >60% in AD patients compared to controls (p50% (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC2707615?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0006294 |
| URL الوصول: | https://doaj.org/article/bcced03af5c344c6b0feea4113bc952a |
| رقم الانضمام: | edsdoj.bcced03af5c344c6b0feea4113bc952a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0006294 |