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An approach to localizing corneal pain representation in human primary somatosensory cortex.

التفاصيل البيبلوغرافية
العنوان: An approach to localizing corneal pain representation in human primary somatosensory cortex.
المؤلفون: Eric A Moulton, Lino Becerra, Perry Rosenthal, David Borsook
المصدر: PLoS ONE, Vol 7, Iss 9, p e44643 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The cornea has been a focus of animal electrophysiological research for decades, but little is known regarding its cortical representation in the human brain. This study attempts to localize the somatotopic representation of the cornea to painful stimuli in human primary somatosensory cortex using functional magnetic resonance imaging (fMRI). In this case study, a subject was imaged at 3T while bright light was presented in a block-design, which either produced pain and blinking (during photophobia) or blinking alone (after recovery from photophobia). Pain and blinking produced precisely localized activations in primary somatosensory cortex and primary motor cortex. These results indicate that noxious stimulation of the cornea can produce somatotopic activation in primary somatosensory cortex. This finding opens future avenues of research to evaluate the relationship between corneal pain and central brain mechanisms relating to the development of chronic pain conditions, such as dry eye-like symptoms.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
92948006
Relation: http://europepmc.org/articles/PMC3433421?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0044643
URL الوصول: https://doaj.org/article/bc9294800633436680a18ec28f6b1a0f
رقم الانضمام: edsdoj.bc9294800633436680a18ec28f6b1a0f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
92948006
DOI:10.1371/journal.pone.0044643