Academic Journal
Quantitative photoacoustic imaging using known chromophores as fluence marker
| العنوان: | Quantitative photoacoustic imaging using known chromophores as fluence marker |
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| المؤلفون: | Anjali Thomas, Max Rietberg, Mervenur Akkus, Gijs van Soest, Kalloor Joseph Francis |
| المصدر: | Photoacoustics, Vol 41, Iss , Pp 100673- (2025) |
| بيانات النشر: | Elsevier, 2025. |
| سنة النشر: | 2025 |
| المجموعة: | LCC:Physics LCC:Acoustics. Sound LCC:Optics. Light |
| مصطلحات موضوعية: | Photoacoustic imaging, Tissue quantification, Optical inversion, Fluence correction, Fluence marker, Spectral imaging, Physics, QC1-999, Acoustics. Sound, QC221-246, Optics. Light, QC350-467 |
| الوصف: | Photoacoustic imaging offers optical contrast images of human tissue at acoustic resolution, making it valuable for diverse clinical applications. However, quantifying tissue composition via optical contrast remains challenging due to the unknown light fluence within the tissue. Here, we propose a method that leverages known chromophores (e.g., arterial blood) to improve the accuracy of quantitative photoacoustic imaging. By using the optical properties of a known chromophore as a fluence marker and integrating it into the optical inversion process, we can estimate the unknown fluence within the tissue. Experimentally, we demonstrate that this approach successfully recovers both the spectral shape and magnitude of the optical absorption coefficient of an unknown chromophore. Additionally, we show that the fluence marker method enhances conventional optical inversion techniques, specifically (i) a straightforward iterative approach and (ii) a gradient-based method. Our results indicate an improvement in accuracy of up to 24.4% when comparing optical absorption recovery with and without the fluence marker. Finally, we present the method’s performance and illustrate its applications in carotid plaque quantification. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-5979 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213597924000909; https://doaj.org/toc/2213-5979 |
| DOI: | 10.1016/j.pacs.2024.100673 |
| URL الوصول: | https://doaj.org/article/bc7e7696d03f4195b34035a3be6dd5d3 |
| رقم الانضمام: | edsdoj.bc7e7696d03f4195b34035a3be6dd5d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22135979 |
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| DOI: | 10.1016/j.pacs.2024.100673 |