Academic Journal
Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect)
| العنوان: | Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect) |
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| المؤلفون: | Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Kouichi Maruyama, Guillaume Varès, Takanori Katsube, Masahiro Murakami, Cuihua Liu, Akira Fujimori, Kazuko Fujita, Qiang Liu, Kiyomi Eguchi-Kasai, Mitsuru Nenoi |
| المصدر: | Dose-Response, Vol 16 (2018) |
| بيانات النشر: | SAGE Publishing, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The existence of radiation-induced adaptive response (AR) was reported in varied biosystems. In mice, the first in vivo AR model was established using X-rays as both the priming and the challenge doses and rescue of bone marrow death as the end point. The underlying mechanism was due to the priming radiation-induced resistance in the blood-forming tissues. In a series of investigations, we further demonstrated the existence of AR using different types of ionizing radiation (IR) including low linear energy transfer (LET) X-rays and high LET heavy ion. In this article, we validated hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony-forming units-spleen (CFU-S) under AR inducible and uninducible conditions using combination of different types of IR. We confirmed the consistency of increased CFU-S number change with the AR inducible condition. These findings suggest that AR in mice induced by different types of IR would share at least in part a common underlying mechanism, the priming IR-induced resistance in the blood-forming tissues, which would lead to a protective effect on the HSCs/HPCs and play an important role in rescuing the animals from bone marrow death. These findings provide a new insight into the mechanistic study on AR in vivo. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1559-3258 15593258 |
| Relation: | https://doaj.org/toc/1559-3258 |
| DOI: | 10.1177/1559325818790152 |
| URL الوصول: | https://doaj.org/article/bbe69bedcd8144c5ad8507aeaa9c337a |
| رقم الانضمام: | edsdoj.bbe69bedcd8144c5ad8507aeaa9c337a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15593258 |
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| DOI: | 10.1177/1559325818790152 |