التفاصيل البيبلوغرافية
| العنوان: |
Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex |
| المؤلفون: |
Farzaneh Najafi, Simone Russo, Jérôme Lecoq |
| المصدر: |
iScience, Vol 28, Iss 2, Pp 111728- (2025) |
| بيانات النشر: |
Elsevier, 2025. |
| سنة النشر: |
2025 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Natural sciences, Biological sciences, Neuroscience, Systems neuroscience, Science |
| الوصف: |
Summary: The visual cortex predicts incoming sensory stimuli through internal models that are updated following unexpected events. Cortical inhibitory neurons, particularly vasoactive intestinal polypeptide (VIP) interneurons, play a critical role in representing unexpected stimuli. Notably, this response is stimulus non-specific, raising the question of what information it conveys. Given their unique connectivity, we hypothesized that during unexpected stimuli, VIP neurons encode broad context signals, referred to here as task-independent information. To test this hypothesis, we analyzed the Allen Institute Visual Behavior dataset, in which mice viewed repeated familiar images and unexpected omissions of these images, while two-photon calcium imaging was performed from distinct cell types across primary and higher-order visual areas. Using dimensionality reduction methods, we found that, in contrast to image presentations, unexpected omissions trigger task-independent signaling in VIP and excitatory neurons. This signaling may facilitate the integration of contextual and sensory information, enabling updated predictions. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004224029559; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2024.111728 |
| URL الوصول: |
https://doaj.org/article/bad6963a4f0a460ea77fa14929c8bccc |
| رقم الانضمام: |
edsdoj.bad6963a4f0a460ea77fa14929c8bccc |
| قاعدة البيانات: |
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