Academic Journal
Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
| العنوان: | Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells |
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| المؤلفون: | Mai Sato, Asako Inohaya, Eriko Yasuda, Haruta Mogami, Yoshitsugu Chigusa, Kaoru Kawasaki, Yosuke Kawamura, Yusuke Ueda, Hiroshi Takai, Masaki Mandai, Eiji Kondoh |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Placental dysfunction is related to the pathogenesis of preeclampsia and fetal growth restriction, but there is no effective treatment for it. Recently, various functional three-dimensional organs have been generated from human induced-pluripotent cells (iPSCs), and the transplantation of these iPSCs-derived organs has alleviated liver failure or diabetes mellitus in mouse models. Here we successfully generated a three-dimensional placental organ bud from human iPSCs. The iPSCs differentiated into various lineages of trophoblasts such as cytotrophoblast-like, syncytiotrophoblast-like, and extravillous trophoblast-like cells, forming organized layers in the bud. Placental buds were transplanted to the murine uterus, where 22% of the buds were successfully engrafted. These iPSC-derived placental organ buds could serve as a new model for the study of placental function and pathology. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-93766-9 |
| URL الوصول: | https://doaj.org/article/ba8c6dea8150421bb252c564d16f6054 |
| رقم الانضمام: | edsdoj.ba8c6dea8150421bb252c564d16f6054 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-93766-9 |