Academic Journal
Hypoglycemic effect of Moringa oleifera (moringa) compared with Smallanthus sonchifolius (yacon) on Rattus norvegicus with induced diabetes mellitus
| العنوان: | Hypoglycemic effect of Moringa oleifera (moringa) compared with Smallanthus sonchifolius (yacon) on Rattus norvegicus with induced diabetes mellitus |
|---|---|
| المؤلفون: | Otto W. Vargas-Tineo, Dina M. Segura-Muñoz, Lizzie K. Becerra-Gutiérrez, José P. Amado-Tineo, Heber Silva-Díaz |
| المصدر: | Revista Peruana de Medicina Experimental y Salud Pública, Vol 37, Iss 3, Pp 478-84 (2020) |
| بيانات النشر: | Instituto Nacional de Salud, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | hipoglicemiante, diabetes mellitus, moringa oleífera, ratas, aloxano, Medicine, Medicine (General), R5-920 |
| الوصف: | Objective: To compare the hypoglycemic effect of the aqueous extract of Moringa oleifera (moringa), Smallanthus sonchifolius (yacon) and metformin on Rattus norvegicus, albino variety, with induced diabetes mellitus. Materials and methods: Preclinical, experimental, controlled and randomized study. Diabetes was induced intraperitoneally with a dose of alloxan at 130 mg/kg. A total of 24 male Rattus norvegicus, albino variety, Holfzman strain (6 per group) were used. They were divided as follows: control group (no treatment), metformin group (14 mg/kg), M. oleifera group (200 mg/kg), and S. sonchifolius group (140 mg/kg), treatments were administered via orogastric tube for 15 days. Glycemia levels were determined using an Accu-Chek® Instant electronic glycometer (Roche). Results: Decreased glycemia was observed in the treatment groups: M. oleifera (p = 0.009), S. sonchifolius (p = 0.002) and metformin (p = 0.002), by 313 mg/dL, 281.5 mg/dL and 415 mg/dL, respectively. When comparing glycemia in the treated and control groups, no difference was observed (P 0.05) at 24 hours and four days of treatment; while at the eighth (P 0.05) and fifteenth day (P 0.01) the treated groups had lower glycemia than the control group, but it was similar among them. Conclusion: The aqueous extract of S. sonchifolius, M. oleifera, and metformin presented similar hypoglycemic effect in experimental rats with induced diabetes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Spanish; Castilian |
| تدمد: | 1726-4634 1726-4642 |
| Relation: | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5275; https://doaj.org/toc/1726-4634; https://doaj.org/toc/1726-4642 |
| DOI: | 10.17843/rpmesp.2020.373.5275 |
| URL الوصول: | https://doaj.org/article/b99ffa1fe71e428b9437fb00242c8410 |
| رقم الانضمام: | edsdoj.b99ffa1fe71e428b9437fb00242c8410 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17264634 17264642 |
|---|---|
| DOI: | 10.17843/rpmesp.2020.373.5275 |