التفاصيل البيبلوغرافية
| العنوان: |
Periprosthetic Joint Infections Caused by Candida Species—A Single-Center Experience and Systematic Review of the Literature |
| المؤلفون: |
Dariusz Grzelecki, Aleksandra Grajek, Piotr Dudek, Łukasz Olewnik, Nicol Zielinska, Petr Fulin, Maria Czubak-Wrzosek, Marcin Tyrakowski, Dariusz Marczak, Jacek Kowalczewski |
| المصدر: |
Journal of Fungi, Vol 8, Iss 8, p 797 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
periprosthetic joint infections, fungal pathogens, Candida albicans, Candida parapsilosis, Biology (General), QH301-705.5 |
| الوصف: |
Background: The aim of this study was to analyze the treatment results of fungal periprosthetic joint infections (PJI) caused by Candida species from a single orthopedic center and to compare them with reports from other institutions. Methods: Eight patients operated on from January 2014 to December 2021 met the inclusion criteria and were analyzed in terms of clinical outcomes. A systematic review of the literature identified 153 patients with Candida PJIs extracted from 12 studies according to the PRISMA (Preferred Reporting Item for Systematic Reviews and Meta-Analyses) guidelines. Results: The success rate of the treatment in the case series was 50%. The most frequent pathogens were Candida albicans (three cases; 37.5%) and Candida parapsilosis (three cases; 37.5%). In one patient (12.5%), bacterial co-infection was noted, and in five patients (62.5%) significant risk factors of PJI were confirmed. The overall success rate on the basis of data collected for systematic review was 65.5%. A sub-analysis of 127 patients revealed statistically significant differences (p = 0.02) with a higher success rate for the knees (77.6%) than for the hips (58%). In 10 studies the analysis of risk factors was performed and among 106 patients in 77 (72.6%) comorbidities predispose to fungal PJI were confirmed. Bacterial co-infection was noted in 84 patients (54.9%). In 93 patients (60.7%) Candida albicans was the culprit pathogen, and in 39 patients (25.5%) Candida parapsilosis was the culprit pathogen. Based on these two most frequent Candida species causing PJI, the success rate of the treatment was statistically different (p = 0.03), and was 60.3% and 83.3%, respectively. The two-stage strategy was more favorable for patients with Candida parapsilosis infections (94.4% success rate) than the one-stage protocol (50% success rate; p = 0.02); as well as in comparison to the two-stage treatment of Candida albicans (65% success rate; p = 0.04). Conclusions: The analysis of the literature showed no differences in the overall success rate between one- and two-stage surgical strategies for all Candida species, but differed significantly comparing the two most frequent strains and concerning PJI localization. The frequent presence of bacterial co-infections makes it necessary to consider the additional administration of antibiotics in the case of fungal PJI. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2309-608X |
| Relation: |
https://www.mdpi.com/2309-608X/8/8/797; https://doaj.org/toc/2309-608X |
| DOI: |
10.3390/jof8080797 |
| URL الوصول: |
https://doaj.org/article/eb90ab944d984670b92659d5d8379b49 |
| رقم الانضمام: |
edsdoj.b90ab944d984670b92659d5d8379b49 |
| قاعدة البيانات: |
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