التفاصيل البيبلوغرافية
| العنوان: |
Intravesical Gemcitabine and Docetaxel Therapy for BCG-Naïve Patients: A Promising Approach to Non-Muscle Invasive Bladder Cancer |
| المؤلفون: |
Mirko Bakula, Tvrtko Hudolin, Nikola Knezevic, Zoran Zimak, Jerko Andelic, Ilija Juric, Marija Gamulin, Milena Gnjidic, Zeljko Kastelan |
| المصدر: |
Life, Vol 14, Iss 7, p 789 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
BCG shortage, non-muscle invasive bladder cancer, BCG-naïve, docetaxel, gemcitabine, Science |
| الوصف: |
Bacillus Calmette-Guérin (BCG) therapy for patients with non-muscle invasive bladder cancer (NMIBC) faces limitations in efficacy and significant side effects, aggravated by a recent global shortage. In this prospective clinical study, we report the outcomes of sequential intravesical administration of gemcitabine and docetaxel (Gem/Doce) as a first-line treatment for BCG-naïve patients with high-risk NMIBC (HR NMIBC). From October 2019 until April 2022, we enrolled 52 patients and followed the treatment protocol set forth by the University of Iowa. Follow-up assessments were conducted every 3 months. In this cohort, 25 (48.1%) patients were diagnosed with high-grade T1 (T1HG) bladder cancer, 10 (19.2%) patients had carcinoma in situ (CIS), and 17 (32.7%) patients had a combination of T1HG+CIS. The median time to first recurrence in the T1HG, CIS, and T1HG+CIS groups was 11, 10.5, and 8.8 months, respectively. The recurrence-free survival was 98.1%, 94.2%, and 80.8% at 6, 9, and 12 months, respectively. The rate of progression-free survival was 100%, 98.1%, and 92.3% at 6, 9, and 12 months, respectively. We demonstrated the safety and efficacy of Gem/Doce therapy in BCG-naïve patients with HR NMIBC during a one-year follow-up. Further research with extended follow-ups, as well as direct comparisons of Gem/Doce with other anticancer agents, is essential. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2075-1729 |
| Relation: |
https://www.mdpi.com/2075-1729/14/7/789; https://doaj.org/toc/2075-1729 |
| DOI: |
10.3390/life14070789 |
| URL الوصول: |
https://doaj.org/article/b8ab768b48db45ef8e593b329a64a7b3 |
| رقم الانضمام: |
edsdoj.b8ab768b48db45ef8e593b329a64a7b3 |
| قاعدة البيانات: |
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