Academic Journal

A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma

التفاصيل البيبلوغرافية
العنوان: A Nutritional Metabolism Related Prognostic Scoring System for Patients With Newly Diagnosed Osteosarcoma
المؤلفون: Longqing Li, Zhuangzhuang Li, Xuanhong He, Yang Wang, Minxun Lu, Taojun Gong, Qing Chang, Jingqi Lin, Yi Luo, Li Min, Yong Zhou, Chongqi Tu
المصدر: Frontiers in Nutrition, Vol 9 (2022)
بيانات النشر: Frontiers Media S.A., 2022.
سنة النشر: 2022
المجموعة: LCC:Nutrition. Foods and food supply
مصطلحات موضوعية: osteosarcoma, nutrition, metabolism, prognosis, hematology, Nutrition. Foods and food supply, TX341-641
الوصف: Osteosarcoma is a primary malignant bone tumor with high metastatic potential. To date, achieving long-term survival of osteosarcoma patients remains a difficult task. Metabolic reprogramming has emerged as a new hallmark of cancer. However, studies on the prognostic value of hematological markers related to nutritional and metabolism in cancer patients are limited and contradictory. In this retrospective study, we extensively collected 16 hematological markers related to nutritional and metabolism in 223 osteosarcoma patients. A nutritional metabolism related prognostic scoring system (NMRS) in patients with osteosarcoma was constructed by least absolute contraction and selection operator (LASSO) cox regression analysis. Compared with individual hematological indicators, NMRS has stronger predictive power (training set: 0.811 vs. 0.362–2.638; validation set: 0.767 vs. 0.333–0.595). It is an independent prognostic factor for the survival of patients with osteosarcoma [HR: 1.957 (1.375–2.786) training set; HR: 3.146 (1.574–6.266) validation set]. NMRS-based nomograms have good and stable predictive power. NMRS facilitates further risk stratification of patients with the same clinical characteristics.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2296-861X
Relation: https://www.frontiersin.org/articles/10.3389/fnut.2022.883308/full; https://doaj.org/toc/2296-861X
DOI: 10.3389/fnut.2022.883308
URL الوصول: https://doaj.org/article/b760ef19b0294882afde0bdecf0f16cd
رقم الانضمام: edsdoj.b760ef19b0294882afde0bdecf0f16cd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2296861X
DOI:10.3389/fnut.2022.883308