Academic Journal
Hepatoprotective activity of the ethanolic extract of Morus indica roots from Indian Bodo tribes
| العنوان: | Hepatoprotective activity of the ethanolic extract of Morus indica roots from Indian Bodo tribes |
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| المؤلفون: | Hankhray Boro, Talambedu Usha, Dinesh Babu, Prakashmurthy Chandana, Arvind Kumar Goyal, Hemavathy Ekambaram, Hasan Soliman Yusufoglu, Sandeep Das, Sushil Kumar Middha |
| المصدر: | SN Applied Sciences, Vol 4, Iss 2, Pp 1-14 (2022) |
| بيانات النشر: | Springer, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Science LCC:Technology |
| مصطلحات موضوعية: | Morus indica L., Mulberry, Polyphenols, Hepatoprotective, Glutathione metabolism, Science, Technology |
| الوصف: | Abstract The roots of Morus species are well described in the Pharmacopoeia of the People's Republic of China (ChP) for its traditional use in treating liver fibrosis due to its hepatoprotective property. However, little is known about the hepatoprotective effect of the roots of Morus indica L. (RoMi), and the pharmacological mechanism(s) are uncertain due to its intricacy. Therefore, this study evaluates the hepatoprotective activity of the ethanolic extract of RoMi (eRoMi) against the CCl4-induced in-vivo animal model at different dosages (100 and 200 mg/kg BW) in comparison with silymarin as a positive control. The hepatoprotective activity of eRoMi was evaluated by measuring the levels of serum biomarkers, hepatic antioxidant enzymes and was verified by histological studies. Interestingly, 1,2-bis(trimethylsilyl) benzene, 1,4-phenylenebis (trimethylsilane), 2,4,6-cycloheptatriene-1-one, 3,5-bis-trimethylsilyl and α-amyrin were the active components found in eRoMi as detected by GC–MS. Oral administration of eRoMi (200 mg/kg BW) to rats significantly protected serum biochemical parameters (increased ALT, AST, LDH, bilirubin and GGT as well as depletion of antioxidant enzymes and hepatic GSH) and elevation in hepatic lipid peroxidation as compared to CCl4-treated rats. The hematological indices such as erythrocytes, hemoglobin, monocytes and lymphocytes were also normal in eRoMi-treated rats. The histopathological evaluation indicated a significant restoration of liver structure as compared to silymarin. This study is the first scientific validation for the traditional use of eRoMi to understand its hepatoprotective activity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2523-3963 2523-3971 |
| Relation: | https://doaj.org/toc/2523-3963; https://doaj.org/toc/2523-3971 |
| DOI: | 10.1007/s42452-021-04859-z |
| URL الوصول: | https://doaj.org/article/db717cf14fd247c6a7031a6917be96ab |
| رقم الانضمام: | edsdoj.b717cf14fd247c6a7031a6917be96ab |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 25233963 25233971 |
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| DOI: | 10.1007/s42452-021-04859-z |