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Protective efficacy of anti-neuraminidase monoclonal antibodies against H7N9 influenza virus infection

التفاصيل البيبلوغرافية
العنوان: Protective efficacy of anti-neuraminidase monoclonal antibodies against H7N9 influenza virus infection
المؤلفون: Fei-Fei Xiong, Xue-Ying Liu, Fei-Xia Gao, Jian Luo, Peng Duan, Wen-Song Tan, Ze Chen
المصدر: Emerging Microbes and Infections, Vol 9, Iss 1, Pp 78-87 (2020)
بيانات النشر: Taylor & Francis Group, 2020.
سنة النشر: 2020
المجموعة: LCC:Infectious and parasitic diseases
LCC:Microbiology
مصطلحات موضوعية: H7N9 influenza virus, neuraminidase, monoclonal antibodies, protection, NA epitope, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
الوصف: ABSTRACTThe H7N9 influenza virus has been circulating in China for more than six years. The neuraminidase (NA) has gained great concern for the development of antiviral drugs, therapeutic antibodies, and new vaccines. In this study, we screened seven mouse monoclonal antibodies (mAbs) and compared their protective effects against H7N9 influenza virus. The epitope mapping from escape mutants showed that all the seven mAbs could bind to the head region of the N9 NA close to the enzyme activity sites, and four key sites of N9 NA were reported for the first time. The mAbs D3 and 7H2 could simultaneously inhibit the cleavage of the sialic acid of fetuin protein with large molecular weight and NA-XTD with small molecule weight in the NA inhibition experiment, prevent the formation of virus plaque at a low concentration, and effectively protect the mice from the challenge of the lethal dose of H7N9 virus.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 22221751
2222-1751
Relation: https://doaj.org/toc/2222-1751
DOI: 10.1080/22221751.2019.1708214
URL الوصول: https://doaj.org/article/b6967c4e02894ecb8493d536d2b55c4c
رقم الانضمام: edsdoj.b6967c4e02894ecb8493d536d2b55c4c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22221751
DOI:10.1080/22221751.2019.1708214