التفاصيل البيبلوغرافية
| العنوان: |
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model |
| المؤلفون: |
Neta Rosenzweig, Raz Dvir-Szternfeld, Afroditi Tsitsou-Kampeli, Hadas Keren-Shaul, Hila Ben-Yehuda, Pierre Weill-Raynal, Liora Cahalon, Alex Kertser, Kuti Baruch, Ido Amit, Assaf Weiner, Michal Schwartz |
| المصدر: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| بيانات النشر: |
Nature Portfolio, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Blocking the PD-1 pathway was shown to be effective in amyloid beta mouse models, yet little is known about its therapeutic potential in models of tauopathy. The authors show here that blocking PD-L1, a PD-1 ligand, is similarly effective, and that both treatments reversed cognitive deficiencies, and modified disease pathology not only in an animal model of AD, but also in the DM-hTAU mouse tauopathy model, through a mechanism that involves monocyte-derived macrophages. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-08352-5 |
| URL الوصول: |
https://doaj.org/article/b5d1dae5c110405690c42c4d4f5633f9 |
| رقم الانضمام: |
edsdoj.b5d1dae5c110405690c42c4d4f5633f9 |
| قاعدة البيانات: |
Directory of Open Access Journals |
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