Academic Journal
Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays
| العنوان: | Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays |
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| المؤلفون: | Brendan Oakes, Xiaoxing Qiu, Susan Levine, John Hackett, Brigitte T. Huber |
| المصدر: | Advances in Virology, Vol 2011 (2011) |
| بيانات النشر: | Hindawi Limited, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | Microbiology, QR1-502 |
| الوصف: | In 2009, Lombardi et al. reported their startling finding that the gammaretrovirus xenotropic murine leukemia virus-related retrovirus (XMRV) is present in 67% of blood samples of patients suffering from chronic fatigue syndrome (CFS), as opposed to only 3.7% of samples from healthy individuals. However, we and others could not confirm these results, using a nested PCR assay. An alternative to this highly sensitive, but contamination-prone, technique is to measure the serological response to XMRV. Thus, we tested the plasma samples from our cohorts of CFS patients and healthy controls for the presence of XMRV-specific antibodies. Using two novel chemiluminescence immunoassays (CMIAs), we show that none of our samples have any XMRV-reactive antibodies. Taken together with our previous findings, we conclude that XMRV is not present in any human individual tested by us, regardless of CFS or healthy control. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-8639 1687-8647 |
| Relation: | https://doaj.org/toc/1687-8639; https://doaj.org/toc/1687-8647 |
| DOI: | 10.1155/2011/854540 |
| URL الوصول: | https://doaj.org/article/b53555e5185c474fb174006627c7a2c8 |
| رقم الانضمام: | edsdoj.b53555e5185c474fb174006627c7a2c8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16878639 16878647 |
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| DOI: | 10.1155/2011/854540 |