Academic Journal
NMDA receptor antagonist high-frequency oscillations are transmitted via bottom-up feedforward processing
| العنوان: | NMDA receptor antagonist high-frequency oscillations are transmitted via bottom-up feedforward processing |
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| المؤلفون: | Jacek Wróbel, Władysław Średniawa, Aleksandra Bramorska, Marian Dovgialo, Daniel Krzysztof Wójcik, Mark Jeremy Hunt |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | NMDAR antagonist, Piriform cortex, Oscillations, Olfactory bulb, Rat, Medicine, Science |
| الوصف: | Abstract In mammals, NMDA receptor antagonists have been linked to the emergence of high-frequency oscillations (HFO, 130–180 Hz) in cortical and subcortical brain regions. The extent to which transmission of this rhythm is dependent on feedforward (bottom-up) or feedback (top-down) mechanisms is unclear. Previously, we have shown that the olfactory bulb (OB), known to orchestrate oscillations in many brain regions, is an important node in the NMDA receptor-dependent HFO network. Since the piriform cortex (PC) receives major input from the OB, and can modulate OB activity via feedback projections, it represents an ideal site to investigate transmission modalities. Here we show, using silicon probes, that NMDA receptor antagonist HFO are present in the PC associated with current dipoles, although of lower power than the OB. Granger causality and peak-lag analyses implicated the OB as the driver of HFO in the PC. Consistent with this, reversible inhibition of the OB resulted in a reduction of HFO power both locally and in the PC. In contrast, inhibition of the PC had minimal impact on OB activity. Collectively, these findings point to bottom-up mechanisms in mediating the transmission of NMDA receptor antagonist-HFO, at least in olfactory circuits. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-71749-w |
| URL الوصول: | https://doaj.org/article/cb4f0a524fdc47dcaf09565cf2c623c6 |
| رقم الانضمام: | edsdoj.b4f0a524fdc47dcaf09565cf2c623c6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-71749-w |