Academic Journal
THE ROLE OF TOLL-LIKE RECEPTORS POLYMORPHISM IN ATHEROSCLEROSIS COMPLICATIONS DEVELOPMENT
| العنوان: | THE ROLE OF TOLL-LIKE RECEPTORS POLYMORPHISM IN ATHEROSCLEROSIS COMPLICATIONS DEVELOPMENT |
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| المؤلفون: | O. L. Barbarash, A. S. Golovkin, A. V. Ponasenko, A. G. Kutikhin, I. I. Zhidkova, M. V. Khutornaya, R. R. Salakhov, L. S. Barbarash |
| المصدر: | Российский кардиологический журнал, Vol 0, Iss 12, Pp 72-79 (2015) |
| بيانات النشر: | «FIRMA «SILICEA» LLC, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | ischemic heart disease, stroke, atherosclerosis, toll-like receptors, gene polymorphism, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Aim. To reveal the association of polymorphic types of Toll-like receptor genes with myocardial infarction (MI), stroke in patients with coronary heart disease (CHD).Material and methods. Totally 292 patients studied, with CHD and anamnesis of stroke and/or MI. The association of 8 polymorphic loci of 4 genes were studied: TLR1 (rs5743551 & rs5743611), TLR2 (rs3804099 & rs5743708), TLR4 (rs4986790 & rs4986791), TLR6 (rs3775073 & rs5743810).Results. The association of allele C of polymorphism rs5743551 gene TLR1 is associated with higher risk of earlier CHD onset (younger than 55 y.o.). Heterozygous (A/G) genotype of polymorphism rs5743810 TLR6 is protective against the risk of earlier CHD onset (younger than 55 y.o.). Heterozygous (C/T) genotype of polymorphism rs5743551 gene TLR1 is associated with higher risk of stroke in CHD patients. The associations revealed with age, gender and cardiovascular complications by polymorphisms of TLR genes: males, having CHD, homozygous by minor allele (С/С) of polymorphism rs3804099 gene TLR2, have reduced risk of of MI development not related to age; heterozygous (C/T) genotype of polymorphism rs5743551 of gene TLR1 is associated with the increased risk of stroke in CHD patients older than 55 y.o. not depending on gender; heterozygous (T/C) genotype of polymorphism rs3775073 gene TLR6 is associated with increased risk of MI in younger than 55 y.o. patients with CHD not related to gender.Conclusion. Some associations of polymorphic Toll-like receptors genes with the development of atherosclerosis complications (MI, stroke) in CHD are revealed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1560-4071 2618-7620 64081826 |
| Relation: | https://russjcardiol.elpub.ru/jour/article/view/480; https://doaj.org/toc/1560-4071; https://doaj.org/toc/2618-7620 |
| DOI: | 10.15829/1560-4071-2015-12-72-79 |
| URL الوصول: | https://doaj.org/article/b4dce88b7cf64081826c67ab8bbb8f84 |
| رقم الانضمام: | edsdoj.b4dce88b7cf64081826c67ab8bbb8f84 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 15604071 26187620 64081826 |
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| DOI: | 10.15829/1560-4071-2015-12-72-79 |