Academic Journal
Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.
| العنوان: | Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis. |
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| المؤلفون: | Takumi Mikawa, Eri Shibata, Midori Shimada, Ken Ito, Tomiko Ito, Hiroaki Kanda, Keiyo Takubo, Atsuyoshi Shimada, Matilde E Lleonart, Nobuya Inagaki, Masayuki Yokode, Hiroshi Kondoh |
| المصدر: | PLoS ONE, Vol 16, Iss 4, p e0250856 (2021) |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Glycolytic metabolism is closely involved in physiological homeostasis and pathophysiological states. Among glycolytic enzymes, phosphoglycerate mutase (PGAM) has been reported to exert certain physiological role in vitro, whereas its impact on glucose metabolism in vivo remains unclear. Here, we report the characterization of Pgam1 knockout mice. We observed that homozygous knockout mice of Pgam1 were embryonic lethal. Although we previously reported that both PGAM-1 and -2 affect global glycolytic profile of cancers in vitro, in vivo glucose parameters were less affected both in the heterozygous knockout of Pgam1 and in Pgam2 transgenic mice. Thus, the impact of PGAM on in vivo glucose metabolism is rather complex than expected before. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0250856 |
| URL الوصول: | https://doaj.org/article/db40f3e5f2f844128fead6d206202821 |
| رقم الانضمام: | edsdoj.b40f3e5f2f844128fead6d206202821 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0250856 |