Academic Journal
The recent advancement of TCR-T cell therapies for cancer treatment
| العنوان: | The recent advancement of TCR-T cell therapies for cancer treatment |
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| المؤلفون: | Zhao Xiang, Shao Shuai, Hu Lanxin |
| المصدر: | Acta Biochimica et Biophysica Sinica, Vol 56, Pp 663-674 (2024) |
| بيانات النشر: | China Science Publishing & Media Ltd., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biochemistry LCC:Genetics |
| مصطلحات موضوعية: | TCR, pMHC, TCR-T cell therapy, tumor antigen, catch bond, dynamic binding, Biochemistry, QD415-436, Genetics, QH426-470 |
| الوصف: | Adoptive cell therapies involve infusing engineered immune cells into cancer patients to recognize and eliminate tumor cells. Adoptive cell therapy, as a form of living drug, has undergone explosive growth over the past decade. The recognition of tumor antigens by the T-cell receptor (TCR) is one of the natural mechanisms that the immune system used to eliminate tumor cells. TCR-T cell therapy, which involves introducing exogenous TCRs into patients’ T cells, is a novel cell therapy strategy. TCR-T cell therapy can target the entire proteome of cancer cells. Engineering T cells with exogenous TCRs to help patients combat cancer has achieved success in clinical trials, particularly in treating solid tumors. In this review, we examine the progress of TCR-T cell therapy over the past five years. This includes the discovery of new tumor antigens, protein engineering techniques for TCR, reprogramming strategies for TCR-T cell therapy, clinical studies on TCR-T cell therapy, and the advancement of TCR-T cell therapy in China. We also propose several potential directions for the future development of TCR-T cell therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1672-9145 |
| Relation: | https://doaj.org/toc/1672-9145 |
| DOI: | 10.3724/abbs.2024034 |
| URL الوصول: | https://doaj.org/article/b2f6eab4a792471bbfc2d195b0210302 |
| رقم الانضمام: | edsdoj.b2f6eab4a792471bbfc2d195b0210302 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16729145 |
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| DOI: | 10.3724/abbs.2024034 |