Academic Journal
Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs
| العنوان: | Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs |
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| المؤلفون: | Andréia Spanamberg, Ana Paula Ravazzolo, Laura B. Denardi, Sydney A. Hartz, Janio M. Santurio, David Driemeier, Laerte Ferreiro |
| المصدر: | Pesquisa Veterinária Brasileira, Vol 40, Iss 2, Pp 102-106 (2020) |
| بيانات النشر: | Colégio Brasileiro de Patologia Animal (CBPA), 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | Aspergillus fumigatus, antifungal, susceptibility, isolates, birds, lungs, Veterinary medicine, SF600-1100 |
| الوصف: | ABSTRACT: Susceptibility testing is essential to inform the correct management of Aspergillus infections. In this study we present antifungal susceptibility profile of A. fumigatus isolates recovered from lungs of birds with and without aspergillosis. Fifty three isolates were tested for their antifungal susceptibility to voriconazole (VRC), itraconazole (ITZ), amphotericin (AMB) and caspofungin (CSP) using the M38-A2 broth microdilution reference method. Five isolates were resistant to more than one antifungal drug (CSP + AMB, VRC + ITZ and AMB + ITZ). Fifteen (28%) isolates with susceptible increased exposure (I) to ITZ were sensible to VRC. Resistance to AMB (>2μg/mL) was observed in only four isolates. Eleven (21%) A. fumigatus present resistance to ITZ (13%) and VRC (8%). Fungal isolation from respiratory samples has been regarded as being of limited usefulness in the ante mortem diagnosis of aspergillosis in birds. However, the results suggest that the detection and antifungal susceptibility profile may be helpful for monitoring of therapy for avian species and where antifungal resistance might be emerging and what conditions are associated to the event. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 1678-5150 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020000200102&tlng=en; http://www.scielo.br/pdf/pvb/v40n2/1678-5150-pvb-40-02-102.pdf; https://doaj.org/toc/1678-5150 |
| DOI: | 10.1590/1678-5150-pvb-6297 |
| URL الوصول: | https://doaj.org/article/b2e3bf03959f4e82af64fa115896441c |
| رقم الانضمام: | edsdoj.b2e3bf03959f4e82af64fa115896441c |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16785150 |
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| DOI: | 10.1590/1678-5150-pvb-6297 |