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Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota

التفاصيل البيبلوغرافية
العنوان: Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
المؤلفون: Junshu Li, Yanhong Ji, Na Chen, Lei Dai, Hongxin Deng
المصدر: Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Biotechnology
LCC:Biology (General)
LCC:Biochemistry
مصطلحات موضوعية: Colitis-associated carcinogenesis, IBD therapy, Intestinal epithelial cells, Intestinal mesenchymal cells, Immune cells, Gut microbiota, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436
الوصف: Abstract Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD). Intestinal epithelial cells (IECs), intestinal mesenchymal cells (IMCs), immune cells, and gut microbiota construct the main body of the colon and maintain colon homeostasis. In the development of colitis and colitis-associated carcinogenesis, the damage, disorder or excessive recruitment of different cells such as IECs, IMCs, immune cells and intestinal microbiota play different roles during these processes. This review aims to discuss the various roles of different cells and the crosstalk of these cells in transforming intestinal inflammation to cancer, which provides new therapeutic methods for chemotherapy, targeted therapy, immunotherapy and microbial therapy.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-3701
Relation: https://doaj.org/toc/2045-3701
DOI: 10.1186/s13578-023-01139-8
URL الوصول: https://doaj.org/article/b2bf52be51af4f85b56c226efed7aa32
رقم الانضمام: edsdoj.b2bf52be51af4f85b56c226efed7aa32
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20453701
DOI:10.1186/s13578-023-01139-8