التفاصيل البيبلوغرافية
| العنوان: |
Nucleolin-Targeting AS1411 Aptamer-Conjugated Nanospheres for Targeted Treatment of Glioblastoma |
| المؤلفون: |
Kyeongjin Seo, Kihwan Hwang, Kyung Mi Nam, Min Ju Kim, Yoon-Kyu Song, Chae-Yong Kim |
| المصدر: |
Pharmaceutics, Vol 16, Iss 4, p 566 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: |
glioblastoma, AS1411, nucleolin, DNA nanostructures, targeted drug delivery, Pharmacy and materia medica, RS1-441 |
| الوصف: |
Post-operative chemotherapy is still required for the treatment of glioblastoma (GBM), for which nanocarrier-based drug delivery has been identified as one of the most effective methods. However, the blood-brain barrier (BBB) and non-specific delivery to non-tumor tissues can significantly limit drug accumulation in tumor tissues and cause damage to nearby normal tissues. This study describes a targeted cancer therapy approach that uses AS1411 aptamer-conjugated nanospheres (100–300 nm in size) loaded with doxorubicin (Dox) to selectively identify tumor cells overexpressing nucleolin (NCL) proteins. The study demonstrates that the active target model, which employs aptamer-mediated drug delivery, is more effective than non-specific enhanced permeability and maintenance (EPR)-mediated delivery and passive drug delivery in improving drug penetration and maintenance in tumor cells. Additionally, the study reveals the potential for anti-cancer effects through 3D spheroidal and in vivo GBM xenograft models. The DNA-protein hybrid nanospheres utilized in this study offer numerous benefits, such as efficient synthesis, structural stability, high drug loading, dye labeling, biocompatibility, and biodegradability. When combined with nanospheres, the 1411 aptamer has been shown to be an effective drug delivery carrier allowing for the precise targeting of tumors. This combination has the potential to produce anti-tumor effects in the active targeted therapy of GBM. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1999-4923 |
| Relation: |
https://www.mdpi.com/1999-4923/16/4/566; https://doaj.org/toc/1999-4923 |
| DOI: |
10.3390/pharmaceutics16040566 |
| URL الوصول: |
https://doaj.org/article/b2ba0b09987d4e36ac26726dca227852 |
| رقم الانضمام: |
edsdoj.b2ba0b09987d4e36ac26726dca227852 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder