Academic Journal
RETRACTED ARTICLE: Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition
| العنوان: | RETRACTED ARTICLE: Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition |
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| المؤلفون: | Matthieu Million, Maryam Tidjani Alou, Saber Khelaifia, Dipankar Bachar, Jean-Christophe Lagier, Niokhor Dione, Souleymane Brah, Perrine Hugon, Vincent Lombard, Fabrice Armougom, Julien Fromonot, Catherine Robert, Caroline Michelle, Aldiouma Diallo, Alexandre Fabre, Régis Guieu, Cheikh Sokhna, Bernard Henrissat, Philippe Parola, Didier Raoult |
| المصدر: | Scientific Reports, Vol 6, Iss 1, Pp 1-11 (2016) |
| بيانات النشر: | Nature Portfolio, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Severe acute malnutrition (SAM) is associated with inadequate diet, low levels of plasma antioxidants and gut microbiota alterations. The link between gut redox and microbial alterations, however, remains unexplored. By sequencing the gut microbiomes of 79 children of varying nutritional status from three centers in Senegal and Niger, we found a dramatic depletion of obligate anaerobes in malnutrition. This was confirmed in an individual patient data meta-analysis including 107 cases and 77 controls from 5 different African and Asian countries. Specifically, several species of the Bacteroidaceae, Eubacteriaceae, Lachnospiraceae and Ruminococceae families were consistently depleted while Enterococcus faecalis, Escherichia coli and Staphylococcus aureus were consistently enriched. Further analyses on our samples revealed increased fecal redox potential, decreased total bacterial number and dramatic Methanobrevibacter smithii depletion. Indeed, M. smithii was detected in more than half of the controls but in none of the cases. No causality was demonstrated but, based on our results, we propose a unifying theory linking microbiota specificity, lacking anaerobes and archaea, to low antioxidant nutrients, and lower food conversion. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/srep26051 |
| URL الوصول: | https://doaj.org/article/b248081813c440a6af297fe257f21c1c |
| رقم الانضمام: | edsdoj.b248081813c440a6af297fe257f21c1c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/srep26051 |