Academic Journal
Fabrication and structural characterization of self-crosslinking hydrogel based on Vietnamese sources of chitosan and alginate
| العنوان: | Fabrication and structural characterization of self-crosslinking hydrogel based on Vietnamese sources of chitosan and alginate |
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| المؤلفون: | Tin Dai Luong, An Tran-My Le, Nhan Thien Vo, Thi Hiep Nguyen |
| المصدر: | Vietnam Journal of Science, Technology and Engineering, Vol 64, Iss 3 (2022) |
| بيانات النشر: | Vietnam Ministry of Science and Technology, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | carboxymethyl chitosan, oxidized alginate, oxidized hyaluronan, self-crosslinking hydrogel, Vietnamese materials, Science |
| الوصف: | Hydrogel materials have attracted extensive research over the last few decades, especially in tissue engineering, due its many comparable properties with native tissue. This study proposes a new approach to hydrogel fabrication that combines oxidized alginate (OA) into N,O-carboxymethyl chitosan (NOCC) and an oxidized hyaluronan-based hydrogel system employing low cost, domestically sourced chitosan and alginate. Hydrogel fabrication parameters including component ratio and hydrogel concentration were studied. Fourier transform infrared spectroscopy (FT-IR) analysis was applied to confirm the chemical structure of the modified materials. Fabricated hydrogel samples were assessed by cross-sectional surface morphology, equilibrium swelling degree, and in vitro degradation behaviour. The results revealed NOCC and oxidized hyaluronic acid (OHA)- OA component contributions toward hydrogel properties, a threshold of raising total polymer content within the network, and a comparison with previous formulations using unmodified alginate. Using low cost domestic resources is a promising way to reduce fabrication expenses, and further work should be performed to evaluate the potential of this cost-effective hydrogel for the tissue engineering field. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2525-2461 2615-9937 |
| Relation: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/1030; https://doaj.org/toc/2525-2461; https://doaj.org/toc/2615-9937 |
| DOI: | 10.31276/VJSTE.64(3).53-61 |
| URL الوصول: | https://doaj.org/article/cb2273b420434b99bdb6ddb24100c518 |
| رقم الانضمام: | edsdoj.b2273b420434b99bdb6ddb24100c518 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 25252461 26159937 |
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| DOI: | 10.31276/VJSTE.64(3).53-61 |