التفاصيل البيبلوغرافية
| العنوان: |
Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila |
| المؤلفون: |
Silvia Schwartz, Sarah J Wilson, Tracy K Hale, Helen L Fitzsimons |
| المصدر: |
Molecular Brain, Vol 16, Iss 1, Pp 1-12 (2023) |
| بيانات النشر: |
BMC, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: |
Ankyrin repeat, Ankyrin2, ANK3, Histone deacetylase, HDAC4, Memory, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: |
Abstract Dysregulation of HDAC4 expression and/or nucleocytoplasmic shuttling results in impaired neuronal morphogenesis and long-term memory in Drosophila melanogaster. A recent genetic screen for genes that interact in the same molecular pathway as HDAC4 identified the cytoskeletal adapter Ankyrin2 (Ank2). Here we sought to investigate the role of Ank2 in neuronal morphogenesis, learning and memory. We found that Ank2 is expressed widely throughout the Drosophila brain where it localizes predominantly to axon tracts. Pan-neuronal knockdown of Ank2 in the mushroom body, a region critical for memory formation, resulted in defects in axon morphogenesis. Similarly, reduction of Ank2 in lobular plate tangential neurons of the optic lobe disrupted dendritic branching and arborization. Conditional knockdown of Ank2 in the mushroom body of adult Drosophila significantly impaired long-term memory (LTM) of courtship suppression, and its expression was essential in the γ neurons of the mushroom body for normal LTM. In summary, we provide the first characterization of the expression pattern of Ank2 in the adult Drosophila brain and demonstrate that Ank2 is critical for morphogenesis of the mushroom body and for the molecular processes required in the adult brain for the formation of long-term memories. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1756-6606 |
| Relation: |
https://doaj.org/toc/1756-6606 |
| DOI: |
10.1186/s13041-023-01026-w |
| URL الوصول: |
https://doaj.org/article/b19a1f7441c94af1a6798d53edaa6e02 |
| رقم الانضمام: |
edsdoj.b19a1f7441c94af1a6798d53edaa6e02 |
| قاعدة البيانات: |
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