التفاصيل البيبلوغرافية
| العنوان: |
Food-Grade Titanium Dioxide Induces Toxicity in the Nematode Caenorhabditis elegans and Acute Hepatic and Pulmonary Responses in Mice |
| المؤلفون: |
Giovanni Sitia, Fabio Fiordaliso, Martina B. Violatto, Jennifer Fernandez Alarcon, Laura Talamini, Alessandro Corbelli, Lorena Maria Ferreira, Ngoc Lan Tran, Indranath Chakraborty, Mario Salmona, Wolfgang J. Parak, Luisa Diomede, Paolo Bigini |
| المصدر: |
Nanomaterials, Vol 12, Iss 10, p 1669 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Chemistry |
| مصطلحات موضوعية: |
titanium dioxide, E171, nanoparticles, C. elegans, mice, toxicity, Chemistry, QD1-999 |
| الوصف: |
Food-grade titanium dioxide (E171) contains variable percentages of titanium dioxide (TiO2) nanoparticles (NPs), posing concerns for its potential effects on human and animal health. Despite many studies, the actual relationship between the physicochemical properties of E171 NPs and their interaction with biological targets is still far from clear. We evaluated the impact of acute E171 administration on invertebrate and vertebrate animals. In the nematode, Caenorhabditis elegans, the administration of up to 1.0 mg/mL of E171 did not affect the worm’s viability and lifespan, but significantly impaired its pharyngeal function, reproduction, and development. We also investigated whether the intravenous administration of E171 in mice (at the dose of 6 mg/kg/body weight) could result in an acute over-absorption of filter organs. A significant increase of hepatic titanium concentration and the formation of microgranulomas were observed. Interstitial inflammation and parenchymal modification were found in the lungs, coupled with titanium accumulation. This was probably due to the propensity of TiO2 NPs to agglomerate, as demonstrated by transmission electron microscopy experiments showing that the incubation of E171 with serum promoted the formation of compact clusters. Overall, these data emphasize the actual risk for human and animal exposure to E171. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2079-4991 |
| Relation: |
https://www.mdpi.com/2079-4991/12/10/1669; https://doaj.org/toc/2079-4991 |
| DOI: |
10.3390/nano12101669 |
| URL الوصول: |
https://doaj.org/article/b1715a2c301c4d43a1ab9673107d16e6 |
| رقم الانضمام: |
edsdoj.b1715a2c301c4d43a1ab9673107d16e6 |
| قاعدة البيانات: |
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