التفاصيل البيبلوغرافية
| العنوان: |
Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery |
| المؤلفون: |
Wen-Wen Lv, Dahai Liu, Xing-Cun Liu, Tie-Nan Feng, Lei Li, Bi-Yun Qian, Wen-Xing Li |
| المصدر: |
BMC Cancer, Vol 18, Iss 1, Pp 1-13 (2018) |
| بيانات النشر: |
BMC, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Hepatocellular carcinoma, PKM2, Metabolic, Overall survival, Drugs, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract Background Hepatocellular carcinoma (HCC) is a malignant tumor that threatens global human health. High PKM2 expression is widely reported in multiple cancers, especially in HCC. This study aimed to explore the effects of PKM2 on global gene expression, metabolic damages, patient prognosis, and multiple transcriptional regulation relationships, as well as to identify several key metabolic genes and screen some small-molecule drugs. Methods Transcriptome and clinical HCC data were downloaded from the NIH-GDC repository. Information regarding the metabolic genes and subsystems was collected from the Recon 2 human metabolic model. Drug-protein interaction data were obtained from the DrugBank and UniProt databases. We defined patients with PKM2 expression levels ≥11.25 as the high-PKM2 group, and those with low PKM2 expression ( |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2407 |
| Relation: |
http://link.springer.com/article/10.1186/s12885-018-5023-0; https://doaj.org/toc/1471-2407 |
| DOI: |
10.1186/s12885-018-5023-0 |
| URL الوصول: |
https://doaj.org/article/b13df30352224851b35aa00101862e23 |
| رقم الانضمام: |
edsdoj.b13df30352224851b35aa00101862e23 |
| قاعدة البيانات: |
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