Academic Journal
BCG vaccination: a role for vitamin D?
| العنوان: | BCG vaccination: a role for vitamin D? |
|---|---|
| المؤلفون: | Maeve K Lalor, Sian Floyd, Patricia Gorak-Stolinska, Rosemary E Weir, Rose Blitz, Keith Branson, Paul E Fine, Hazel M Dockrell |
| المصدر: | PLoS ONE, Vol 6, Iss 1, p e16709 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | BCG vaccination is administered in infancy in most countries with the aim of providing protection against tuberculosis. There is increasing interest in the role of vitamin D in immunity to tuberculosis. This study objective was to determine if there was an association between circulating 25(OH)D concentrations and BCG vaccination status and cytokine responses following BCG vaccination in infants.Blood samples were collected from UK infants who were vaccinated with BCG at 3 (n = 47) and 12 (n = 37) months post BCG vaccination. These two time-points are denoted as time-point 1 and time-point 2. Two blood samples were also collected from age-matched unvaccinated infants (n = 32 and 28 respectively), as a control group. Plasma vitamin D concentrations (25(OH)D) were measured by radio-immunoassay. The cytokine IFNγ was measured in supernatants from diluted whole blood stimulated with M.tuberculosis (M.tb) PPD for 6 days.58% of infants had some level of hypovitaminosis (25(OH)D |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3031626?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0016709 |
| URL الوصول: | https://doaj.org/article/b0d8dc385c834f8aaebe4d3bf10c547f |
| رقم الانضمام: | edsdoj.b0d8dc385c834f8aaebe4d3bf10c547f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0016709 |