التفاصيل البيبلوغرافية
| العنوان: |
Severe SARS-CoV-2 Breakthrough Reinfection With Delta Variant After Recovery From Breakthrough Infection by Alpha Variant in a Fully Vaccinated Health Worker |
| المؤلفون: |
Jayanthi Shastri, Swapneil Parikh, Veena Aggarwal, Sachee Agrawal, Nirjhar Chatterjee, Rajit Shah, Priti Devi, Priyanka Mehta, Rajesh Pandey |
| المصدر: |
Frontiers in Medicine, Vol 8 (2021) |
| بيانات النشر: |
Frontiers Media S.A., 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, reinfection, breakthrough, whole genome sequencing, breakthrough reinfection, Medicine (General), R5-920 |
| الوصف: |
Background: Post infection immunity and post vaccination immunity both confer protection against COVID-19. However, there have been many whole genome sequencing proven reinfections and breakthrough infections. Both are most often mild and caused by Variants of Concern (VOC).Methods: The patient in our study underwent serial COVID-19 RT-PCR, blood tests for serology, acute phase reactants, and chest imaging as part of clinical care. We interviewed the patient for clinical history and retrieved reports and case papers. We retrieved stored RT-PCR positive samples for whole genome sequencing (WGS) of SARS-CoV-2 from the patient's breakthrough infections and the presumed index case.Findings: The patient had three RT-PCR confirmed SARS-CoV-2 infections. Two breakthrough infections occurred in quick succession with the first over 3 weeks after complete vaccination with COVISHIELD and despite post-vaccination seroconversion. The first breakthrough infection was due to the Alpha variant and the second due to the Delta variant. The Delta variant infection resulted in hypoxia, hospitalization, and illness lasting seven weeks. Serial serology, acute phase reactants, and chest imaging supported WGS in establishing distinct episodes of infection. WGS established a fully vaccinated family member as the index case.Interpretation: The patient had an Alpha variant breakthrough infection despite past infection, complete vaccination, and seroconversion. Despite boosting after this infection, the patient subsequently had a severe Delta variant breakthrough infection. This was also a WGS proven reinfection and, therefore, a case of breakthrough reinfection. The patient acquired the infection from a fully vaccinated family member. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2021.737007/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2021.737007 |
| URL الوصول: |
https://doaj.org/article/b0bca6f1f21d4cb993f40b1c9351e790 |
| رقم الانضمام: |
edsdoj.b0bca6f1f21d4cb993f40b1c9351e790 |
| قاعدة البيانات: |
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