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Development of microsurgical forceps equipped with haptic technology for in situ differentiation of brain tumors during microsurgery

التفاصيل البيبلوغرافية
العنوان: Development of microsurgical forceps equipped with haptic technology for in situ differentiation of brain tumors during microsurgery
المؤلفون: Taketo Ezaki, Kouki Kishima, Shunsuke Shibao, Takuya Matsunaga, Eriel Sandika Pareira, Yohei Kitamura, Yuji Nakayama, Noboru Tsuda, Kento Takahara, Takashi Iwama, Oltea Sampetrean, Masahiro Toda, Kouhei Ohnishi, Tomoyuki Shimono, Hikaru Sasaki
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Haptics, Microsurgery, Artificial intelligence (AI), Glioblastoma, Tumor stiffness, Medicine, Science
الوصف: Abstract The stiffness of human cancers may be correlated with their pathology, and can be used as a biomarker for diagnosis, malignancy prediction, molecular expression, and postoperative complications. Neurosurgeons perform tumor resection based on tactile sensations. However, it takes years of surgical experience to appropriately distinguish brain tumors from surrounding parenchymal tissue. Haptics is a technology related to the touch sensation. Haptic technology can amplify, transmit, record, and reproduce real sensations, and the physical properties (e.g., stiffness) of an object can be quantified. In the present study, glioblastoma (SF126-firefly luciferase-mCherry [FmC], U87-FmC, U251-FmC) and malignant meningioma (IOMM-Lee-FmC, HKBMM-FmC) cell lines were transplanted into nude mice, and the stiffness of tumors and normal brain tissues were measured using our newly developed surgical forceps equipped with haptic technology. We found that all five brain tumor tissues were stiffer than normal brain tissue (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-72326-x
URL الوصول: https://doaj.org/article/b09b9e186dce4046a9458890b62d736d
رقم الانضمام: edsdoj.b09b9e186dce4046a9458890b62d736d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-72326-x