التفاصيل البيبلوغرافية
| العنوان: |
Stromal area differences with epithelial-mesenchymal transition gene changes in conjunctival and orbital mucosa-associated lymphoid tissue lymphoma |
| المؤلفون: |
Mizuki Tagami, Hiroaki Kasashima, Anna Kakehashi, Atsuko Yoshikawa, Mizuho Nishio, Norihiko Misawa, Atsushi Sakai, Hideki Wanibuchi, Masakazu Yashiro, Atsushi Azumi, Shigeru Honda |
| المصدر: |
Frontiers in Oncology, Vol 14 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
ocular adnexa MALT lymphoma, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type, RNA sequencing, epithelial-mesenchymal transition, vimentin, tumor stroma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
PurposeTo examine the molecular biological differences between conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma and orbital MALT lymphoma in ocular adnexa lymphoma.MethodsObservational case series. A total of 129 consecutive, randomized cases of ocular adnexa MALT lymphoma diagnosed histopathologically between 2008 and 2020.Total RNA was extracted from formalin-fixed paraffin-embedded tissue from ocular adnexa MALT lymphoma, and RNA-sequencing was performed. Orbital MALT lymphoma gene expression was compared with that of conjunctival MALT lymphoma. Gene set (GS) analysis detecting for gene set cluster was performed in RNA-sequence. Related proteins were further examined by immunohistochemical staining. In addition, artificial segmentation image used to count stromal area in HE images.ResultsGS analysis showed differences in expression in 29 GS types in primary orbital MALT lymphoma (N=5,5, FDR q-value 1) independent of age and sex on multivariate analysis (P=0.004). Stroma area in tumor were significant difference(P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2024.1277749/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2024.1277749 |
| URL الوصول: |
https://doaj.org/article/a9fe5161a886491c98eeb784e38352f1 |
| رقم الانضمام: |
edsdoj.9fe5161a886491c98eeb784e38352f1 |
| قاعدة البيانات: |
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