Academic Journal
Micro Spectroscopic Photoacoustic (μsPA) imaging of advanced carotid atherosclerosis
| العنوان: | Micro Spectroscopic Photoacoustic (μsPA) imaging of advanced carotid atherosclerosis |
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| المؤلفون: | Sophinese Iskander-Rizk, Mirjam Visscher, Astrid M. Moerman, Suze-Anne Korteland, Kim Van der Heiden, Antonius F.W. Van der Steen, Gijs Van Soest |
| المصدر: | Photoacoustics, Vol 22, Iss , Pp 100261- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Physics LCC:Acoustics. Sound LCC:Optics. Light |
| مصطلحات موضوعية: | Microscopy, Spectroscopy, Mass spectrometry imaging, Lipids, Atherosclerosis, PCA, Physics, QC1-999, Acoustics. Sound, QC221-246, Optics. Light, QC350-467 |
| الوصف: | Atherosclerosis is a lipid-driven and an inflammatory disease of the artery walls. The composition of atherosclerotic plaque stratifies the risk of a specific plaque to cause a cardiovascular event. In an optical resolution photoacoustic microscopy setup, of 45 μm resolution, we extracted plaque lipid photoacoustic (PA) spectral signatures of human endarterectomy samples in the range of 1150–1240 nm, using matrix assisted laser desorption ionization mass spectrometry imaging as a reference. We found plaque PA signals to correlate best with sphingomyelins and cholesteryl esters. PA signal spectral variations within the plaque area were compared to reference molecular patterns and absorption spectra of lipid laboratory standards. Variability in the lipid spectroscopic features extracted by principal component analysis of all samples revealed three distinct components with peaks at: 1164, 1188, 1196 and 1210 nm. This result will guide the development of PA-based atherosclerosis disease staging capitalizing on lipidomics of atherosclerotic tissue. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-5979 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213597921000227; https://doaj.org/toc/2213-5979 |
| DOI: | 10.1016/j.pacs.2021.100261 |
| URL الوصول: | https://doaj.org/article/9fc0569b4b144586990f1a38b44fd887 |
| رقم الانضمام: | edsdoj.9fc0569b4b144586990f1a38b44fd887 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22135979 |
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| DOI: | 10.1016/j.pacs.2021.100261 |