التفاصيل البيبلوغرافية
| العنوان: |
Antifibrotic Drug Delivery for Glaucoma Treatment – Determination of Josamycin in vivo |
| المؤلفون: |
Eickner Thomas, Huling Jennifer, Oschatz Stefan, Lange Helge, Peil Anita, Undre Nasrullah, Stachs Oliver, Stahnke Thomas, Grabow Niels, Jünemann Anselm, Fuellen Georg |
| المصدر: |
Current Directions in Biomedical Engineering, Vol 10, Iss 4, Pp 224-227 (2024) |
| بيانات النشر: |
De Gruyter, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
drug delivery, antifibrotic, glaucoma surgery, mass spectrometry, in vivo application, Medicine |
| الوصف: |
Antifibrotic treatment during glaucoma surgery leads to an improved outcome for patients. Drug delivery systems for placement under the subconjuctiva after surgery made of cyclodextrins and crosslinked with Epichlorohydin were loaded with Josamycin and tested in vivo. After subconjunctival application in three New Zealand White rabbits, blood samples were taken by the means of Mitra devices at defined time points. Determination of blood levels of Josamycin was performed using liquid chromatography mass spectrometry. Detection of Josamycin was achieved during 48 h suggesting a sustained release over the course of this study. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2364-5504 |
| Relation: |
https://doaj.org/toc/2364-5504 |
| DOI: |
10.1515/cdbme-2024-2054 |
| URL الوصول: |
https://doaj.org/article/9f438aeb18be4dc1b7bce853695f855f |
| رقم الانضمام: |
edsdoj.9f438aeb18be4dc1b7bce853695f855f |
| قاعدة البيانات: |
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