Academic Journal
Progress and application of adipose-derived stem cells in the treatment of diabetes and its complications
| العنوان: | Progress and application of adipose-derived stem cells in the treatment of diabetes and its complications |
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| المؤلفون: | Dongxu Yan, Yujie Song, Bing Zhang, Guojie Cao, Haitao Zhou, Hong Li, Hao Sun, Meng Deng, Yufeng Qiu, Wei Yi, Yang Sun |
| المصدر: | Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-32 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Adipose-derived stem cells, Cell therapy, Diabetes mellitus, Complications, Diabetic wounds, Retinopathy, Medicine (General), R5-920, Biochemistry, QD415-436 |
| الوصف: | Abstract Diabetes mellitus (DM) is a serious chronic metabolic disease that can lead to many serious complications, such as cardiovascular disease, retinopathy, neuropathy, and kidney disease. Once diagnosed with diabetes, patients need to take oral hypoglycemic drugs or use insulin to control blood sugar and slow down the progression of the disease. This has a significant impact on the daily life of patients, requiring constant monitoring of the side effects of medication. It also imposes a heavy financial burden on individuals, their families, and even society as a whole. Adipose-derived stem cells (ADSCs) have recently become an emerging therapeutic modality for DM and its complications. ADSCs can improve insulin sensitivity and enhance insulin secretion through various pathways, thereby alleviating diabetes and its complications. Additionally, ADSCs can promote tissue regeneration, inhibit inflammatory reactions, and reduce tissue damage and cell apoptosis. The potential mechanisms of ADSC therapy for DM and its complications are numerous, and its extensive regenerative and differentiation ability, as well as its role in regulating the immune system and metabolic function, make it a powerful tool in the treatment of DM. Although this technology is still in the early stages, many studies have already proven its safety and effectiveness, providing new treatment options for patients with DM or its complications. Although based on current research, ADSCs have achieved some results in animal experiments and clinical trials for the treatment of DM, further clinical trials are still needed before they can be applied in a clinical setting. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1757-6512 |
| Relation: | https://doaj.org/toc/1757-6512 |
| DOI: | 10.1186/s13287-023-03620-0 |
| URL الوصول: | https://doaj.org/article/9f12e9ee053b4e6d9a6662e89ce568f3 |
| رقم الانضمام: | edsdoj.9f12e9ee053b4e6d9a6662e89ce568f3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17576512 |
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| DOI: | 10.1186/s13287-023-03620-0 |