التفاصيل البيبلوغرافية
| العنوان: |
Lesson from nature: Zataria multiflora nanostructured lipid carrier topical gel formulation against Candida-associated onychomycosis, a randomized double-blind placebo-controlled clinical trial |
| المؤلفون: |
Maryam Moazeni, Hamidreza Kelidari, Yaser Nasirzadehfard, Tahereh Shokohi, Behrad Roohi, Zohreh Hajheidari, Armaghan Kazeminejad, Shima Parsay, Kofi Asare-Addo, Ali Nokhodchi |
| المصدر: |
Medicine in Drug Discovery, Vol 22, Iss , Pp 100187- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: |
Zataria multiflora, Nano-structured lipid carrier, Clinical trials, Candida, Onychomycosis, Pharmacy and materia medica, RS1-441 |
| الوصف: |
Purpose: The increasing resistance to onychomycosis treatment globally is a major concern as it results in treatment failures. This research aimed to investigate the effectiveness of incorporating nanostructured lipid carriers (NLCs) in a gel formulation for treating mild to moderate Candida-associated onychomycosis using Zataria multiflora (Zt) essential oils. Methods: The characteristics of Zataria multiflora-loaded nanostructured lipid carriers (Zt-NLCs) were validated using a carbopol gel (1 % w/w). In vitro tests were conducted using CLSI M60 standards to evaluate the susceptibility of ten commonly encountered dermatophyte species to antifungal agents. A clinical study was conducted involving 40 volunteers randomly assigned to two groups: one receiving the Zt-NLCs gel and the other receiving a placebo, using a double-blind, placebo-controlled design. The objective was to assess clinical manifestations and mycological findings after topical application for 2 and 4 weeks. The causative agents' species were identified using a PCR-RFLP method. Results: The preparation of Zt-NLCs gel resulted in a uniform suspension of spherical nanoparticles with favourable characteristics and no cytotoxic effects. Zt-NLCs demonstrated significant inhibitory effects on fungal growth and effectively improved clinical and mycological criteria in comparison to the placebo group (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2590-0986 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2590098624000125; https://doaj.org/toc/2590-0986 |
| DOI: |
10.1016/j.medidd.2024.100187 |
| URL الوصول: |
https://doaj.org/article/d9ee77d0bc7b42a0b09b120fb20a9f43 |
| رقم الانضمام: |
edsdoj.9ee77d0bc7b42a0b09b120fb20a9f43 |
| قاعدة البيانات: |
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