Academic Journal
Real-world dose escalation of biologics for moderate-to-severe psoriasis in the United States
| العنوان: | Real-world dose escalation of biologics for moderate-to-severe psoriasis in the United States |
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| المؤلفون: | Jashin J. Wu, Manish Patel, Feng Zeng, Ahong Huang, Xing Pan, Yiwen Cao, Naijun Chen, Huzefa Photowala, Vishvas Garg, Jeff Crowley |
| المصدر: | Journal of Dermatological Treatment, Vol 34, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | psoriasis, real-world data, dose escalation, Dermatology, RL1-803 |
| الوصف: | Aim To compare real-world dose escalation of risankizumab with other US Food and Drug Administration (FDA)-approved biologic treatments for management of moderate-to-severe psoriasis (PsO) in the United States. Methods The Merative® MarketScan® Research Database was used to identify adults with ≥2 medical claims for PsO, ≥3 claims of the index biologic medication in the maintenance period, and ≥6 months continuous enrollment pre-induction and ≥6 months after initiation of the maintenance period. Dose escalation was defined as ≥2 dosing intervals where the average daily dose was ≥30% higher than the expected daily dose (per FDA-approved dosing). Comparisons between risankizumab and other cohorts were made using chi-square tests and logistic regression models. Results At the 30% threshold, the percentage of patients with dose escalation in the full maintenance period was significantly lower with risankizumab (2.0%) compared with other drug classes (tumor necrosis factor, interleukin (IL)-12/23, IL-17, or other IL-23 inhibitors: 17.6%, 10.0%, 18.3%, or 7.1%, respectively; p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0954-6634 1471-1753 09546634 |
| Relation: | https://doaj.org/toc/0954-6634; https://doaj.org/toc/1471-1753 |
| DOI: | 10.1080/09546634.2023.2200869 |
| URL الوصول: | https://doaj.org/article/a9d47e3c0a2d49c78d55c475b09339ae |
| رقم الانضمام: | edsdoj.9d47e3c0a2d49c78d55c475b09339ae |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 09546634 14711753 |
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| DOI: | 10.1080/09546634.2023.2200869 |