Academic Journal
Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment
| العنوان: | Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment |
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| المؤلفون: | Li Huang, Huaqiang Fang, Teng Zhang, Binbin Hu, Shichen Liu, Fanzhen Lv, Zhaoxia Zeng, Huijie Liu, Weimin Zhou, Xiaolei Wang |
| المصدر: | Bioactive Materials, Vol 23, Iss , Pp 526-538 (2023) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| مصطلحات موضوعية: | Photothermal responsive, Drug delivery, Microneedles, Atherosclerosis, Drug-eluting balloon, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| الوصف: | Drug-eluting balloon (DEB) angioplasty has emerged as an effective treatment for cardiovascular and cerebrovascular diseases. However, distal embolism and late lumen restenosis could be caused by drug loss during DEB handling and rapid drug metabolization. Here, a drug-loaded balloon equipped with tip-separable microneedles on the balloon surface (MNDLB) was developed. Inbuilt near-infrared (NIR) ring laser inside the catheter inner shaft was introduced to activate the biodegradable microneedle tips for the first time. The drug-loaded tips thus could be embedded in the vasculature and then released antiproliferative drug – paclitaxel slowly via polymer degradation for more than half a year. A significant increase in drug delivery efficiency and superior therapeutic effectiveness compared with the standard DEB were demonstrated using an atherosclerosis rabbit model. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X22004790; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2022.11.015 |
| URL الوصول: | https://doaj.org/article/9d28c79ab6e2459bacd7a0215e4d2715 |
| رقم الانضمام: | edsdoj.9d28c79ab6e2459bacd7a0215e4d2715 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2022.11.015 |