Academic Journal
Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma
| العنوان: | Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma |
|---|---|
| المؤلفون: | Brigita Glebauskiene, Rasa Liutkeviciene, Alvita Vilkeviciute, Loresa Kriauciuniene, Giedrimantas Bernotas, Arimantas Tamasauskas, Dalia Zaliuniene |
| المصدر: | Scientifica, Vol 2016 (2016) |
| بيانات النشر: | Hindawi Limited, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Purpose. To determine if the frequency of the genotype of MMP-2 (-1306 C/T) Rs243865 has an influence on the development of pituitary adenoma (PA). Methods. The study enrolled n=84 patients with PA and a random sample of the population n=318 (reference group). The genotyping test of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method. Results. Analysis of MMP-2 (-1306 C/T) gene polymorphism has not revealed any differences in the genotype (C/C, C/T, and T/T) distribution between the PA patients and the reference group (as follows: 50%, 44%, and 6% versus 59.75%, 33.96%, and 6.29%). MMP-2 (-1306) C/C genotype was rarely observed in noninvasive PA compared to healthy controls: 35.1% versus 59.75%; p=0.0049, as well C/C genotype being more frequently detected in nonrecurrence PA compared to healthy controls: 46.5% versus 59.75%; p=0.0468. MMP-2 (-1306) C/T genotype was more frequently present in PA females compared to healthy controls females: 49.1% versus 33.66%; p=0.041. Conclusion. Patients with noninvasive and nonrecurrence pituitary adenoma were the carriers of the C/C genotype significantly more frequently than their control counterparts and the C/T genotype in females was more frequent. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-908X |
| Relation: | https://doaj.org/toc/2090-908X |
| DOI: | 10.1155/2016/2839697 |
| URL الوصول: | https://doaj.org/article/9d241dbb43bf4262a85278dc8e5d990a |
| رقم الانضمام: | edsdoj.9d241dbb43bf4262a85278dc8e5d990a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2090908X |
|---|---|
| DOI: | 10.1155/2016/2839697 |