التفاصيل البيبلوغرافية
| العنوان: |
HSP70 and Primary Arterial Hypertension |
| المؤلفون: |
Bernardo Rodriguez-Iturbe, Richard J. Johnson, Laura Gabriela Sanchez-Lozada, Hector Pons |
| المصدر: |
Biomolecules, Vol 13, Iss 2, p 272 (2023) |
| بيانات النشر: |
MDPI AG, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
HSP70, hypertension, immune reactivity, inflammation, Microbiology, QR1-502 |
| الوصف: |
Heat shock protein 70 (HSP70) production is a stress-generated cellular response with high interspecies homology. HSP70 has both chaperone and cytokine functions and may induce, depending on the context, tolerogenic anti-inflammatory reactivity or immunogenic and autoimmune reactivity. Intracellular (chaperoning transit of antigens to MHC in antigen-presenting cells) and extracellular HSP70-related effects are associated with hypertension, which is an inflammatory condition recognized as the most important risk factor for cardiovascular disease mortality. Here, we review (a) the relationship between HSP70, inflammation and immune reactivity, (b) clinical evidence relating to stress, HSP70 and anti-HSP70 reactivity with primary hypertension and (c) experimental data showing that salt-sensitive hypertension is associated with delayed hypersensitivity to HSP70. This is a consequence of anti-HSP70 reactivity in the kidneys and may be prevented and corrected by the T-cell-driven inhibition of kidney inflammation triggered by specific epitopes of HSP70. Finally, we discuss our postulate that lifelong stress signals and danger-associated molecular patterns stimulate HSP-70 and individual genetic and epigenetic characteristics determine whether the HSP70 response would drive inflammatory immune reactivity causing hypertension or, alternatively, would drive immunomodulatory responses that protect against hypertension. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2218-273X |
| Relation: |
https://www.mdpi.com/2218-273X/13/2/272; https://doaj.org/toc/2218-273X |
| DOI: |
10.3390/biom13020272 |
| URL الوصول: |
https://doaj.org/article/9c76f1b791124c2a9dc7c472de00e71a |
| رقم الانضمام: |
edsdoj.9c76f1b791124c2a9dc7c472de00e71a |
| قاعدة البيانات: |
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