التفاصيل البيبلوغرافية
| العنوان: |
Increased FKBP51 in induced sputum cells of chronic obstructive pulmonary disease patients after therapy |
| المؤلفون: |
Holownia A, Mroz R M, Kolodziejczyk A, Chyczewska E, Braszko J J |
| المصدر: |
European Journal of Medical Research, Vol 14, Iss Suppl 4, Pp 108-111 (2009) |
| بيانات النشر: |
BMC, 2009. |
| سنة النشر: |
2009 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
budesonide, FKBP51, formoterol, glucocorticoids, theophylline, Medicine |
| الوصف: |
Abstract Objective Immunophilin FKBP51 assists polypeptide folding, participates in glucocorticoid actions and may play a role in glucocorticoid resistance. FKBP51 is altered in patients with asthma, but its role in chronic obstructive pulmonary disease (COPD) characterized by dysregulation of several pro/antiinflammatory genes is less clear. Methods We assessed changes in nuclear/cytosolic FKBP51 protein using SDS-PAGE/WB and FKBP51 mRNA by qRT-PCR in cells isolated from induced sputum of stable COPD patients treated with formoterol/budesonide or formoterol/budesonide/theophylline for 4 wk. Results Expression of FKBP51 was higher in formoterol/budesonide/theophylline-treated patients, compared with formoterol/budesonide group in both cytosolic and nuclear fractions by about 57% and 31%, respectively (P < 0.001, P < 0.01). FKBP51 mRNA was only slightly, but not significantly, higher in patients on formoterol/budesonide/theophylline. Conclusions Increased FKBP51 in COPD patients treated with formoterol/budesonide/theophylline may be important in altering signaling from corticosteroid receptors. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2047-783X |
| Relation: |
http://www.eurjmedres.com/content/14/S4/108; https://doaj.org/toc/2047-783X |
| DOI: |
10.1186/2047-783X-14-S4-108 |
| URL الوصول: |
https://doaj.org/article/9bdbfdeb176146aa864622e0c6939b33 |
| رقم الانضمام: |
edsdoj.9bdbfdeb176146aa864622e0c6939b33 |
| قاعدة البيانات: |
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