Academic Journal
Characteristics and phenotypes of a COPD cohort from referral hospital clinics in Uganda
| العنوان: | Characteristics and phenotypes of a COPD cohort from referral hospital clinics in Uganda |
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| المؤلفون: | Trishul Siddharthan, John R Hurst, Bruce Kirenga, Levicatus Mugenyi, Winceslaus Katagira, Alex Kayongo, Rupert Jones, Patricia Alupo, Joanitah Nalunjogi |
| المصدر: | BMJ Open Respiratory Research, Vol 11, Iss 1 (2024) |
| بيانات النشر: | BMJ Publishing Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | Medicine, Diseases of the respiratory system, RC705-779 |
| الوصف: | Introduction Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with varied clinical and pathophysiological characteristics. Although there is increasing evidence that COPD in low-income and middle-income countries may have different clinical characteristics from that in high-income countries, little is known about COPD phenotypes in these settings. We describe the clinical characteristics and risk factor profile of a COPD population in Uganda.Methods We cross sectionally analysed the baseline clinical characteristics of 323 patients with COPD aged 30 years and above who were attending 2 national referral outpatient facilities in Kampala, Uganda between July 2019 and March 2021. Logistic regression was used to determine factors associated with spirometric disease severity.Results The median age was 62 years; 51.1% females; 93.5% scored COPD Assessment Test >10; 63.8% modified medical research council (mMRC) >2; 71.8% had wheezing; 16.7% HIV positive; 20.4% had a history of pulmonary tuberculosis (TB); 50% with blood eosinophilic count >3%, 51.7% had 3 or more exacerbations in the past year. Greater severity by Global initiative for Chronic Obstructive Lung Disease (GOLD) stage was inversely related to age (aOR=0.95, 95% CI 0.92 to 0.97), and obesity compared with underweight (aOR=0.25, 95% CI 0.07 to 0.82). Regarding clinical factors, more severe airflow obstruction was associated with SPO2 |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2052-4439 |
| Relation: | https://bmjopenrespres.bmj.com/content/11/1/e001816.full; https://doaj.org/toc/2052-4439 |
| DOI: | 10.1136/bmjresp-2023-001816 |
| URL الوصول: | https://doaj.org/article/9b78555d066e4868898f7920bed857c3 |
| رقم الانضمام: | edsdoj.9b78555d066e4868898f7920bed857c3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20524439 |
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| DOI: | 10.1136/bmjresp-2023-001816 |