Academic Journal
Risk of osteoporosis and fracture in long-term breast cancer survivors
| العنوان: | Risk of osteoporosis and fracture in long-term breast cancer survivors |
|---|---|
| المؤلفون: | Jieon Go, Suyeon Park, Kyeong Sik Kim, Min Chang Kang, Myong Hoon Ihn, Sangchul Yun, Sang Hyun Kim, Sung Hoon Hong, Jong Eun Lee, Sun Wook Han, Sung Yong Kim, Zisun Kim, Sung Mo Hur, Jihyoun Lee |
| المصدر: | Korean Journal of Clinical Oncology, Vol 16, Iss 1, Pp 39-45 (2020) |
| بيانات النشر: | Korean Society of Surgical Oncology, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Surgery |
| مصطلحات موضوعية: | breast neoplasms, survivorship, osteoporosis, osteoporotic fracture, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Surgery, RD1-811 |
| الوصف: | Purpose High incidence of osteoporosis has been reported in breast cancer patients due to early menopause triggered by adjuvant treatment and temporary ovarian function suppression. In this study, we sought to determine whether long-term breast cancer survivors had an elevated risk of low bone density compared to the general population. Methods Long-term breast cancer survivors who had been treated for more than 5 years were selected for this study. Data were obtained from medical records and using a questionnaire from the Korea National Health and Nutrition Examination Survey (KNHANES). An age-matched non-cancer control group was selected from the KNHANES records. Incidence of fracture and bone mineral density (BMD) were compared between the two groups. Results In total, 74 long-term breast cancer survivors and 296 non-cancer controls were evaluated. The incidence of fracture did not differ between the two groups (P=0.130). No differences were detected in lumbar BMD (P=0.051) following adjustment for body mass index, while hip BMD was significantly lower in breast cancer survivors (P=0.028). Chemotherapy and endocrine treatment were not related to low BMD in breast cancer survivors. In more than half of the survivors, the 10-year risk of osteoporotic fracture was less than 1%. Conclusion Long-term breast cancer survivors had low bone density but a comparable risk of fracture compared to non-cancer age-matched controls. Further studies on the factors related to low bone density in long-term breast cancer survivors are required. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1738-8082 2288-4084 |
| Relation: | http://www.kjco.org/upload/kjco-16-1-39.pdf; https://doaj.org/toc/1738-8082; https://doaj.org/toc/2288-4084 |
| DOI: | 10.14216/kjco.20007 |
| URL الوصول: | https://doaj.org/article/9b4fad23ecbd4a1db525ec9005067eef |
| رقم الانضمام: | edsdoj.9b4fad23ecbd4a1db525ec9005067eef |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17388082 22884084 |
|---|---|
| DOI: | 10.14216/kjco.20007 |