Academic Journal
The central nervous system is a potential reservoir and possible origin of drug resistance in hepatitis B infection
| العنوان: | The central nervous system is a potential reservoir and possible origin of drug resistance in hepatitis B infection |
|---|---|
| المؤلفون: | Lijun Xu, Minghan Zhou, Xiuming Peng, Yufan Xu, Fan Huang, Linyun Wang, Xiaorong Peng, Zongxing Yang, Ran Tao, Guanjing Lang, Qing Cao, Minwei Li, Ying Huang, Biao Zhu, Yan Xu |
| المصدر: | Journal of Virus Eradication, Vol 9, Iss 3, Pp 100348- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Microbiology LCC:Public aspects of medicine |
| مصطلحات موضوعية: | HBV, Cerebrospinal fluid, Sequence, Mutation, Microbiology, QR1-502, Public aspects of medicine, RA1-1270 |
| الوصف: | Background: The significance of hepatitis B virus (HBV) in cerebrospinal fluid (CSF) is unclear. Methods: Synchronous serum and CSF samples were collected from 13 patients. HBV DNA, full-length genome, quasispecies, phylogenetic tree, compartmentalization and mutation of the reverse transcriptase (RT) region were performed based on PCR and sequencing methods. Results: HBV DNA was detected in the CSF of 3 antiviral-naïve individuals and 1 individual after successful antiviral therapy. Complete full-length HBV genomes were isolated from the CSF of 5 individuals, including 2 with undetectable serum HBV DNA. Ten individuals exhibited distinct CSF-serum quasispecies, 8 harbored independent CSF-serum genetic compartmentalization and phylogenetic trees, and 5 lamivudine/entecavir-associated resistance mutations only in the CSF. The frequencies of rtL180M and rtM204I/V mutations in both serum and CSF were higher in HIV-HBV-coinfected individuals than in the HBV-monoinfected ones (serum: rtL180M: 3.9% vs. 0, P = 0.004; rtM204I/V: 21.3% vs. 0, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2055-6640 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2055664023000341; https://doaj.org/toc/2055-6640 |
| DOI: | 10.1016/j.jve.2023.100348 |
| URL الوصول: | https://doaj.org/article/9aeac24e13694697b77e6141af5ae8ea |
| رقم الانضمام: | edsdoj.9aeac24e13694697b77e6141af5ae8ea |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20556640 |
|---|---|
| DOI: | 10.1016/j.jve.2023.100348 |